PCYT1A

PCYT1A
Identifiers
Aliases	PCYT1A, CCTA, CT, CTA, CTPCT, PCYT1, SMDCRD, phosphate cytidylyltransferase 1, choline, alpha, phosphate cytidylyltransferase 1A, choline, CCTalpha
External IDs	OMIM: 123695 MGI: 88557 HomoloGene: 3680 GeneCards: PCYT1A
Gene location (Human) Chr. Chromosome 3 (human) Band 3q29 Start 196,214,222 bp End 196,287,957 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16 B3|16 22.69 cM Start 32,249,739 bp End 32,293,888 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve monocyte skin of abdomen duodenum blood tibia nipple stromal cell of endometrium muscle of leg internal globus pallidus Top expressed in triceps brachii muscle temporal muscle epithelium of stomach extensor digitorum longus muscle digastric muscle sternocleidomastoid muscle plantaris muscle jejunum duodenum knee joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotidyltransferase activity catalytic activity protein homodimerization activity lipid binding choline-phosphate cytidylyltransferase activity calmodulin binding phosphatidylcholine binding Cellular component cytoplasm cytosol membrane endoplasmic reticulum membrane glycogen granule nuclear envelope endoplasmic reticulum plasma membrane Biological process biosynthesis lipid metabolism phospholipid biosynthetic process phosphatidylcholine biosynthetic process CDP-choline pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5130 13026 Ensembl ENSG00000161217 ENSMUSG00000005615 UniProt P49585 P49586 RefSeq (mRNA) NM_005017 NM_001312673 NM_001163159 NM_001163160 NM_009981 RefSeq (protein) NP_001299602 NP_005008 NP_001156631 NP_001156632 NP_034111 Location (UCSC) Chr 3: 196.21 – 196.29 Mb Chr 16: 32.25 – 32.29 Mb PubMed search
Wikidata
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Choline-phosphate cytidylyltransferase A is an enzyme that in humans is encoded by the PCYT1A gene.

Further reading

• Hunt AN, Normand CS, Postle AD (1990). "CTP:cholinephosphate cytidylyltransferase in human and rat lung: association in vitro with cytoskeletal actin". Biochim. Biophys. Acta. 1043 (1): 19–26. doi:10.1016/0005-2760(90)90105-7. PMID 2155660.
• Vance JE, Vance DE (1988). "Does rat liver Golgi have the capacity to synthesize phospholipids for lipoprotein secretion?". J. Biol. Chem. 263 (12): 5898–909. doi:10.1016/S0021-9258(18)60650-7. PMID 2833521.
• Weinhold PA, Feldman DA (1995). "Fatty acids promote the formation of complexes between choline-phosphate cytidylyltransferase and cytidylyltransferase binding protein". Arch. Biochem. Biophys. 318 (1): 147–56. doi:10.1006/abbi.1995.1215. PMID 7726555.
• Johnson JE, Cornell RB (1994). "Membrane-binding amphipathic alpha-helical peptide derived from CTP:phosphocholine cytidylyltransferase". Biochemistry. 33 (14): 4327–35. doi:10.1021/bi00180a029. PMID 8155650.
• Dunne SJ, Cornell RB, Johnson JE, et al. (1996). "Structure of the membrane binding domain of CTP:phosphocholine cytidylyltransferase". Biochemistry. 35 (37): 11975–84. doi:10.1021/bi960821+. PMID 8810902.
• Arnold RS, DePaoli-Roach AA, Cornell RB (1997). "Binding of CTP:phosphocholine cytidylyltransferase to lipid vesicles: diacylglycerol and enzyme dephosphorylation increase the affinity for negatively charged membranes". Biochemistry. 36 (20): 6149–56. doi:10.1021/bi970023z. PMID 9166786.
• Yang J, Wang J, Tseu I, et al. (1997). "Identification of an 11-residue portion of CTP-phosphocholine cytidylyltransferase that is required for enzyme-membrane interactions". Biochem. J. 325. ( Pt 1) (Pt 1): 29–38. doi:10.1042/bj3250029. PMC 1218525. PMID 9224626.
• Lykidis A, Baburina I, Jackowski S (1999). "Distribution of CTP:phosphocholine cytidylyltransferase (CCT) isoforms. Identification of a new CCTbeta splice variant". J. Biol. Chem. 274 (38): 26992–7001. doi:10.1074/jbc.274.38.26992. PMID 10480912.
• Lagace TA, Miller JR, Ridgway ND (2002). "Caspase processing and nuclear export of CTP:phosphocholine cytidylyltransferase alpha during farnesol-induced apoptosis". Mol. Cell. Biol. 22 (13): 4851–62. doi:10.1128/MCB.22.13.4851-4862.2002. PMC 133913. PMID 12052891.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Guenther MG, Yu J, Kao GD, et al. (2003). "Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex". Genes Dev. 16 (24): 3130–5. doi:10.1101/gad.1037502. PMC 187500. PMID 12502735.
• Xie M, Smith JL, Ding Z, et al. (2004). "Membrane binding modulates the quaternary structure of CTP:phosphocholine cytidylyltransferase". J. Biol. Chem. 279 (27): 28817–25. doi:10.1074/jbc.M403311200. PMID 15069071.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Enaw JO, Zhu H, Yang W, et al. (2007). "CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California population". BMC Medicine. 4: 36. doi:10.1186/1741-7015-4-36. PMC 1770928. PMID 17184542.