PCGEM1

Not to be confused with PC GEM.

PCGEM1
Identifiers
Aliases	PCGEM1, LINC00071, NCRNA00071, PCAT9, prostate-specific transcript (non-protein coding), prostate-specific transcript, PCGEM1 prostate-specific transcript
External IDs	OMIM: 605443 GeneCards: PCGEM1
Gene location (Human) Chr. Chromosome 2 (human) Band 2q32.3 Start 192,749,845 bp End 192,776,899 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence prostate prefrontal cortex monocyte reproductive organ amygdala islet of Langerhans muscle of leg kidney gastrocnemius muscle n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 64002 n/a Ensembl ENSG00000227418 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 2: 192.75 – 192.78 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Prostate-specific transcript 1
Predicted secondary structure and sequence conservation of PCGEM1
Identifiers
Symbol	PCGEM1
Rfam	RF01981
Other data
RNA type	Gene;
Domain(s)	Eukaryota;
GO	GO:0042981
SO	SO:0001463
PDB structures	PDBe

Prostate-specific transcript 1 (non-protein coding), also known as PCGEM1, is a long non-coding RNA gene. In humans, it is located on chromosome 2q32. It is over-expressed in prostate cancer. In a study of prostate tumours from 88 men, levels of PCGEM1 were found to be higher in prostate cancer cells in African-American men than in Caucasian-American men. The mortality rate of prostate cancer is highest in African-American men.

PCGEM1 inhibits doxorubicin-induced apoptosis of cells, via delayed induction of p53 and p21.

See also

• Long noncoding RNA
• Prostate cancer

Further reading

• Ifere GO, Barr E, Equan A, et al. (2009). "Differential effects of cholesterol and phytosterols on cell proliferation, apoptosis and expression of a prostate specific gene in prostate cancer cell lines". Cancer Detect. Prev. 32 (4): 319–328. doi:10.1016/j.cdp.2008.12.002. PMID 19186008.
• Enciso-Mora V, Hosking FJ, Houlston RS (2010). "Risk of breast and prostate cancer is not associated with increased homozygosity in outbred populations". Eur. J. Hum. Genet. 18 (8): 909–914. doi:10.1038/ejhg.2010.53. PMC 2987391. PMID 20407466.
• Romanuik TL, Wang G, Morozova O, Delaney A, Marra MA, Sadar MD (2010). "LNCaP Atlas: gene expression associated with in vivo progression to castration-recurrent prostate cancer". BMC Med. Genom. 3: 43. doi:10.1186/1755-8794-3-43. PMC 2956710. PMID 20868494.
• Ifere GO, Ananaba GA (November 2009). "Prostate cancer gene expression marker 1 (PCGEM1): a patented prostate- specific non-coding gene and regulator of prostate cancer progression". Recent Pat DNA Gene Seq. 3 (3): 151–163. doi:10.2174/187221509789318360. PMID 19891595.

External links

• Page for Prostate-specific transcript 1 at Rfam