Protein-coding gene in the species Homo sapiens
PAS domain-containing protein 1 is a protein that in humans is encoded by the PASD1 gene .[3] [4] [5]
PASD1 has been shown to inhibit the transcriptional activity between CLOCK and BMAL1 which appears to be co-opted in cancer cells to attenuate clock function.[6] [7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000166049 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Liggins AP, Guinn BA, Hatton CS, Pulford K, Banham AH (July 2004). "Serologic detection of diffuse large B-cell lymphoma-associated antigens" . International Journal of Cancer . 110 (4): 563–569. doi :10.1002/ijc.20170 PMID 15122589 . ^ Liggins AP, Brown PJ, Asker K, Pulford K, Banham AH (July 2004). "A novel diffuse large B-cell lymphoma-associated cancer testis antigen encoding a PAS domain protein" . British Journal of Cancer . 91 (1): 141–149. doi :10.1038/sj.bjc.6601875 . PMC 2364759 PMID 15162151 . ^ "Entrez Gene: PASD1 PAS domain containing 1" .^ Michael AK, Harvey SL, Sammons PJ, Anderson AP, Kopalle HM, Banham AH, Partch CL (June 2015). "Cancer/Testis Antigen PASD1 Silences the Circadian Clock" . Molecular Cell . 58 (5): 743–754. doi :10.1016/j.molcel.2015.03.031 . PMC 4458219 PMID 25936801 . ^ Greenwood V (15 September 2015). "How the Body's Trillions of Clocks Keep Time" . Quanta Magazine
Further reading
Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination" . Genome Research . 10 (11): 1788–1795. doi :10.1101/gr.143000 . PMC 310948 PMID 11076863 . Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing" . EMBO Reports . 1 (3): 287–292. doi :10.1093/embo-reports/kvd058 . PMC 1083732 PMID 11256614 . Guinn BA, Bland EA, Lodi U, Liggins AP, Tobal K, Petters S, et al. (October 2005). "Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia". Biochemical and Biophysical Research Communications . 335 (4): 1293–1304. doi :10.1016/j.bbrc.2005.08.024 . PMID 16112646 . Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Research . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 .
