PAFAH1B2

PAFAH1B2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1VYH
Identifiers
Aliases	PAFAH1B2, HEL-S-303, platelet activating factor acetylhydrolase 1b catalytic subunit 2
External IDs	OMIM: 602508 MGI: 108415 HomoloGene: 1932 GeneCards: PAFAH1B2
Gene location (Human) Chr. Chromosome 11 (human) Band 11q23.3 Start 117,144,284 bp End 117,176,894 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A5.2 Start 45,962,859 bp End 46,012,690 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte pons inferior ganglion of vagus nerve superior vestibular nucleus trigeminal ganglion subthalamic nucleus middle temporal gyrus ventral tegmental area parietal lobe postcentral gyrus Top expressed in spermatid spermatocyte renal corpuscle neural tube somite maxillary prominence supraoptic nucleus ganglionic eminence dorsomedial hypothalamic nucleus habenula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function 1-alkyl-2-acetylglycerophosphocholine esterase activity platelet-activating factor acetyltransferase activity hydrolase activity protein homodimerization activity protein heterodimerization activity phospholipase A2 activity protein binding Cellular component plasma membrane nucleolus extracellular exosome fibrillar center extracellular region cytoplasm cytosol secretory granule lumen ficolin-1-rich granule lumen Biological process lipid catabolic process positive regulation of macroautophagy brain development spermatogenesis lipid metabolism neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5049 18475 Ensembl ENSG00000168092 ENSMUSG00000003131 UniProt P68402 Q61206 RefSeq (mRNA) NM_001184746 NM_001184747 NM_001184748 NM_001309431 NM_002572 NM_008775 RefSeq (protein) NP_001171675 NP_001171676 NP_001171677 NP_001296360 NP_002563 NP_032801 NP_001344167 NP_001344168 NP_001344169 NP_001344170 NP_001344172 NP_001344173 NP_001344174 NP_001344175 Location (UCSC) Chr 11: 117.14 – 117.18 Mb Chr 9: 45.96 – 46.01 Mb PubMed search
Wikidata
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Platelet-activating factor acetylhydrolase IB subunit beta is an enzyme that in humans is encoded by the PAFAH1B2 gene.

Interactions

PAFAH1B2 has been shown to interact with PAFAH1B1.

See also

• PAFAH1B1
• PAFAH1B3

Further reading

• Albrecht U, Abu-Issa R, Rätz B, Hattori M, Aoki J, Arai H, Inoue K, Eichele G (Dec 1996). "Platelet-activating factor acetylhydrolase expression and activity suggest a link between neuronal migration and platelet-activating factor". Developmental Biology. 180 (2): 579–93. doi:10.1006/dbio.1996.0330. PMID 8954729.
• Sweeney KJ, Clark GD, Prokscha A, Dobyns WB, Eichele G (Apr 2000). "Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development". Mechanisms of Development. 92 (2): 263–71. doi:10.1016/S0925-4773(00)00242-2. PMID 10727864.
• Sheffield PJ, McMullen TW, Li J, Ho YS, Garrard SM, Derewenda U, Derewenda ZS (Jul 2001). "Preparation and crystal structure of the recombinant alpha(1)/alpha(2) catalytic heterodimer of bovine brain platelet-activating factor acetylhydrolase Ib". Protein Engineering. 14 (7): 513–9. doi:10.1093/protein/14.7.513. PMID 11522926.
• Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A (Apr 2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Molecular & Cellular Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
• Bruneel A, Labas V, Mailloux A, Sharma S, Royer N, Vinh J, Pernet P, Vaubourdolle M, Baudin B (Oct 2005). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169. S2CID 26007149.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Hasstedt SJ, Scott BT, Rosendaal FR, Callas PW, Vossen CY, Long GL, Bovill EG (Sep 2007). "Exclusion of the alpha2 subunit of platelet-activating factor acetylhydrolase 1b (PAFAH1B2) as a prothrombotic gene in a protein C-deficient kindred and population-based case-control sample". Thrombosis and Haemostasis. 98 (3): 587–92. doi:10.1160/th07-02-0134. PMID 17849047. S2CID 7180897.