PACSIN3

PACSIN3
Identifiers
Aliases	PACSIN3, SDPIII, protein kinase C and casein kinase substrate in neurons 3
External IDs	OMIM: 606513 MGI: 1891410 HomoloGene: 41117 GeneCards: PACSIN3
Gene location (Human) Chr. Chromosome 11 (human) Band 11p11.2 Start 47,177,522 bp End 47,186,443 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 E1 Start 91,086,299 bp End 91,095,024 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle body of tongue left ventricle left adrenal gland sural nerve triceps brachii muscle minor salivary glands right lobe of liver body of stomach left uterine tube Top expressed in interventricular septum temporal muscle skeletal muscle tissue digastric muscle sternocleidomastoid muscle triceps brachii muscle esophagus soleus muscle lip extraocular muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytoskeletal protein binding calcium channel inhibitor activity protein binding lipid binding phospholipid binding Cellular component endosome plasma membrane extracellular exosome membrane cytoplasm cytosol cytoskeleton Biological process regulation of endocytosis negative regulation of endocytosis positive regulation of membrane protein ectodomain proteolysis endocytosis plasma membrane tubulation negative regulation of calcium ion transport regulation of molecular function cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29763 80708 Ensembl ENSG00000165912 ENSMUSG00000027257 UniProt Q9UKS6 Q99JB8 RefSeq (mRNA) NM_016223 NM_001184974 NM_001184975 NM_001289677 NM_001289678 NM_028733 NM_030880 RefSeq (protein) NP_001171903 NP_001171904 NP_057307 NP_001276606 NP_001276607 NP_083009 NP_112019 Location (UCSC) Chr 11: 47.18 – 47.19 Mb Chr 2: 91.09 – 91.1 Mb PubMed search
Wikidata
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Protein kinase C and casein kinase substrate in neurons protein 3 is an enzyme that in humans is encoded by the PACSIN3 gene.

Interactions

PACSIN3 has been shown to interact with PACSIN1 and PACSIN2.

Further reading

• Modregger J, Ritter B, Witter B, et al. (2001). "All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis". J. Cell Sci. 113. Pt 24 (24): 4511–21. doi:10.1242/jcs.113.24.4511. PMID 11082044.
• Sumoy L, Pluvinet R, Andreu N, et al. (2001). "PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family". Gene. 262 (1–2): 199–205. doi:10.1016/S0378-1119(00)00531-X. PMID 11179684.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mori S, Tanaka M, Nanba D, et al. (2003). "PACSIN3 binds ADAM12/meltrin alpha and up-regulates ectodomain shedding of heparin-binding epidermal growth factor-like growth factor". J. Biol. Chem. 278 (46): 46029–34. doi:10.1074/jbc.M306393200. PMID 12952982.
• Schulze WX, Mann M (2004). "A novel proteomic screen for peptide-protein interactions". J. Biol. Chem. 279 (11): 10756–64. doi:10.1074/jbc.M309909200. PMID 14679214.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Onodera Y, Hashimoto S, Hashimoto A, et al. (2005). "Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities". EMBO J. 24 (5): 963–73. doi:10.1038/sj.emboj.7600588. PMC 554134. PMID 15719014.
• Cuajungco MP, Grimm C, Oshima K, et al. (2006). "PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4". J. Biol. Chem. 281 (27): 18753–62. doi:10.1074/jbc.M602452200. hdl:2066/51163. PMID 16627472.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.