OBSL1

OBSL1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2CPC, 2E6P, 2E6Q, 2LU7, 2LVC, 2WP3, 2WWK, 2WWM, 3KNB
Identifiers
Aliases	OBSL1, obscurin like 1, obscurin like cytoskeletal adaptor 1
External IDs	OMIM: 610991 HomoloGene: 28013 GeneCards: OBSL1
Gene location (Human) Chr. Chromosome 2 (human) Band 2q35 Start 219,550,728 bp End 219,571,859 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland left lobe of thyroid gland right uterine tube anterior pituitary left uterine tube canal of the cervix body of pancreas gastric mucosa left ventricle tibial nerve n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytoskeletal anchor activity protein binding structural constituent of muscle actin filament binding muscle alpha-actinin binding structural molecule activity conferring elasticity Cellular component Z disc 3M complex intercalated disc M band centrosome microtubule organizing center cytoskeleton cytoplasm Golgi apparatus perinuclear region of cytoplasm muscle myosin complex cytosol striated muscle thin filament sarcomere Biological process protein localization to Golgi apparatus cardiac myofibril assembly microtubule cytoskeleton organization cytoskeleton organization regulation of mitotic nuclear division positive regulation of dendrite morphogenesis Golgi organization striated muscle contraction actin filament organization sarcomere organization striated muscle myosin thick filament assembly post-translational protein modification muscle contraction skeletal muscle thin filament assembly skeletal muscle myosin thick filament assembly cardiac muscle tissue morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23363 n/a Ensembl ENSG00000124006 n/a UniProt O75147 n/a RefSeq (mRNA) NM_001173408 NM_001173431 NM_015311 n/a RefSeq (protein) NP_001166879 NP_001166902 NP_056126 n/a Location (UCSC) Chr 2: 219.55 – 219.57 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Obscurin-like protein 1 is a protein that in humans is encoded by the OBSL1 gene.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Geisler SB, Robinson D, Hauringa M, et al. (2007). "Obscurin-like 1, OBSL1, is a novel cytoskeletal protein related to obscurin". Genomics. 89 (4): 521–31. doi:10.1016/j.ygeno.2006.12.004. PMC 1885211. PMID 17289344.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

External links

• GeneReviews/NIH/NCBI/UW entry on 3-M syndrome
• OMIM entries on 3-M syndrome
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Obscurin-like protein 1 (OBSL1)