Non-histone protein
In chromatin, those proteins which remain after the histones have been removed, are classified as non-histone proteins. The non-histone proteins, are a large group of heterogeneous proteins that play a role in organization and compaction of the chromosome into higher order structures. They play vital roles in regulating processes like nucleosome remodeling, DNA replication, RNA synthesis and processing, nuclear transport, steroid hormone action and interphase/mitosis transition.[1] Scaffold proteins, DNA polymerase, Heterochromatin Protein 1 and Polycomb are common non-histone proteins. This classification group also includes numerous other structural, regulatory, and motor proteins. Non-histone protein are acidic.
The methylation of non-histone proteins regulates responses to DNA damage including the modulation of DNA repair pathways in proliferating and post-mitotic neuronal cells.[2] Such modulation likely has implications for neuronal function.[2]
See also
References
- ^ Fedele, Monica (2006). Encyclopedic reference of genomics and proteomics in molecular medicine. Berlin: Springer. doi:10.1007/3-540-29623-9_2690. ISBN 978-3-540-29623-2. Retrieved 9 September 2020.
- ^ a b Urulangodi M, Mohanty A. DNA damage response and repair pathway modulation by non-histone protein methylation: implications in neurodegeneration. J Cell Commun Signal. 2020 Mar;14(1):31-45. doi: 10.1007/s12079-019-00538-2. Epub 2019 Nov 20. Erratum in: J Cell Commun Signal. 2021 Mar;15(1):151. PMID: 31749026; PMCID: PMC7176765
Sources
Hartwell, Leland; L. Hood; M. Goldberg; A. Reynolds; L. Silver; R. Veres (2004). Genetics: From Genes to Genomes. New York, NY: McGraw-Hill. pp. 417–422. ISBN 0-07-246248-5.