NPRL2

NPRL2
Identifiers
Aliases	NPRL2, NPR2, NPR2L, TUSC4, NPR2-like, GATOR1 complex subunit, FFEVF2, NPR2 like, GATOR1 complex subunit
External IDs	OMIM: 607072 MGI: 1914482 HomoloGene: 4771 GeneCards: NPRL2
Gene location (Human) Chr. Chromosome 3 (human) Band 3p21.31 Start 50,347,330 bp End 50,350,826 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 F1 Start 107,419,425 bp End 107,422,905 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas pituitary gland anterior pituitary prefrontal cortex Brodmann area 9 blood cingulate gyrus gastrocnemius muscle nucleus accumbens vastus lateralis muscle Top expressed in interventricular septum proximal tubule spermatocyte neural tube superior frontal gyrus secondary oocyte thymus right ventricle spermatid lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase activity protein binding GTPase activator activity Cellular component GATOR1 complex lysosome lysosomal membrane membrane Biological process negative regulation of TOR signaling cellular response to amino acid starvation negative regulation of kinase activity positive regulation of GTPase activity protein phosphorylation cellular response to nitrogen starvation positive regulation of autophagy regulation of autophagosome assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10641 56032 Ensembl ENSG00000114388 ENSMUSG00000010057 UniProt Q8WTW4 Q9WUE4 RefSeq (mRNA) NM_006545 NM_018879 RefSeq (protein) NP_006536 NP_061367 Location (UCSC) Chr 3: 50.35 – 50.35 Mb Chr 9: 107.42 – 107.42 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Nitrogen permease regulator 2-like protein (NPRL2) also known as tumor suppressor candidate 4 (TUSC4) is a protein that in humans is encoded by the NPRL2 gene.

Further reading

• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Ueda K, Kawashima H, Ohtani S, Deng WG, Ravoori M, Bankson J, Gao B, Girard L, Minna JD, Roth JA, Kundra V, Ji L (Oct 2006). "The 3p21.3 tumor suppressor NPRL2 plays an important role in cisplatin-induced resistance in human non-small-cell lung cancer cells". Cancer Research. 66 (19): 9682–90. doi:10.1158/0008-5472.CAN-06-1483. PMID 17018626.
• Li J, Wang F, Haraldson K, Protopopov A, Duh FM, Geil L, Kuzmin I, Minna JD, Stanbridge E, Braga E, Kashuba VI, Klein G, Lerman MI, Zabarovsky ER (Sep 2004). "Functional characterization of the candidate tumor suppressor gene NPRL2/G21 located in 3p21.3C". Cancer Research. 64 (18): 6438–43. doi:10.1158/0008-5472.CAN-03-3869. PMID 15374952.
• Ji L, Nishizaki M, Gao B, Burbee D, Kondo M, Kamibayashi C, Xu K, Yen N, Atkinson EN, Fang B, Lerman MI, Roth JA, Minna JD (May 2002). "Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo". Cancer Research. 62 (9): 2715–20. PMC 3478680. PMID 11980673.