NOTUM (gene)

NOTUM
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UYU, 4UYW, 4UYZ, 4UZ1, 4UZ5, 4UZ6, 4UZ7, 4UZ9, 4UZA, 4UZL, 4UZQ, 4WBH
Identifiers
Aliases	NOTUM, hpalmitoleoyl-protein carboxylesterase
External IDs	OMIM: 609847 MGI: 1924833 HomoloGene: 45335 GeneCards: NOTUM
Gene location (Human) Chr. Chromosome 17 (human) Band 17q25.3 Start 81,952,507 bp End 81,961,840 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 E2 Start 120,544,614 bp End 120,552,001 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vena cava striated muscle tissue pylorus thymus right lobe of liver nipple pericardium pons superior frontal gyrus gastrocnemius muscle Top expressed in molar optic chiasm proximal tubule lens liver left lobe of liver renal pelvis kidney morula left lung lobe More reference expression data BioGPS n/a
Gene ontology Molecular function palmitoleyl hydrolase activity carboxylic ester hydrolase activity hydrolase activity phospholipase C activity Cellular component extracellular region endoplasmic reticulum lumen Biological process negative regulation of Wnt signaling pathway protein depalmitoleylation Wnt signaling pathway negative regulation of canonical Wnt signaling pathway post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 147111 77583 Ensembl ENSG00000185269 ENSMUSG00000042988 UniProt Q6P988 Q8R116 RefSeq (mRNA) NM_178493 NM_175263 NM_001382269 NM_001382270 RefSeq (protein) NP_848588 NP_780472 NP_001369198 NP_001369199 Location (UCSC) Chr 17: 81.95 – 81.96 Mb Chr 11: 120.54 – 120.55 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Notum, palmitoleoyl-protein carboxylesterase is a protein that in humans is encoded by the NOTUM gene.

Further reading

• Torisu Y, Watanabe A, Nonaka A, Midorikawa Y, Makuuchi M, Shimamura T, Sugimura H, Niida A, Akiyama T, Iwanari H, Kodama T, Zeniya M, Aburatani H (June 2008). "Human homolog of NOTUM, overexpressed in hepatocellular carcinoma, is regulated transcriptionally by beta-catenin/TCF". Cancer Sci. 99 (6): 1139–46. doi:10.1111/j.1349-7006.2008.00814.x. PMID 18429952. S2CID 13526819.
• Kakugawa S, Langton PF, Zebisch M, Howell S, Chang TH, Liu Y, Feizi T, Bineva G, O'Reilly N, Snijders AP, Jones EY, Vincent JP (March 2015). "Notum deacylates Wnt proteins to suppress signalling activity". Nature. 519 (7542): 187–192. Bibcode:2015Natur.519..187K. doi:10.1038/nature14259. PMC 4376489. PMID 25731175.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Palmitoleoyl-protein carboxylesterase NOTUM