NAP1L4

NAP1L4
Identifiers
Aliases	NAP1L4, NAP1L4b, NAP2, NAP2L, hNAP2, nucleosome assembly protein 1 like 4
External IDs	OMIM: 601651 MGI: 1316687 HomoloGene: 133933 GeneCards: NAP1L4
Gene location (Human) Chr. Chromosome 11 (human) Band 11p15.4 Start 2,944,431 bp End 2,992,377 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 F5|7 88.24 cM Start 143,513,579 bp End 143,549,106 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence Achilles tendon bone marrow cells sural nerve gastrocnemius muscle minor salivary glands anterior pituitary appendix Brodmann area 9 rectum Top expressed in saccule ectoderm otic placode lens medullary collecting duct superior cervical ganglion primitive streak renal corpuscle spermatocyte ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function unfolded protein binding protein binding RNA binding nucleosome binding Cellular component nucleus cytoplasm Biological process nucleosome assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4676 17955 Ensembl ENSG00000205531 ENSG00000273562 ENSMUSG00000059119 UniProt Q99733 Q78ZA7 RefSeq (mRNA) NM_005969 NM_001285489 NM_001285490 NM_008672 RefSeq (protein) NP_005960 NP_001356304 NP_001356305 NP_001356306 NP_001356307 NP_001356308 NP_001356309 NP_001356310 NP_001356311 NP_001356312 NP_001356313 NP_001356314 NP_001356315 NP_001356317 NP_005960.1 NP_001272418 NP_001272419 NP_032698 Location (UCSC) Chr 11: 2.94 – 2.99 Mb Chr 7: 143.51 – 143.55 Mb PubMed search
Wikidata
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Nucleosome assembly protein 1-like 4 is a protein that in humans is encoded by the NAP1L4 gene.

This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer.

Further reading

• Rodriguez P, Munroe D, Prawitt D, et al. (1997). "Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone". Genomics. 44 (3): 253–65. doi:10.1006/geno.1997.4868. PMID 9325046.
• Rodriguez P, Pelletier J, Price GB, Zannis-Hadjopoulos M (2000). "NAP-2: histone chaperone function and phosphorylation state through the cell cycle". J. Mol. Biol. 298 (2): 225–38. doi:10.1006/jmbi.2000.3674. PMID 10764593.
• Shikama N, Chan HM, Krstic-Demonacos M, et al. (2000). "Functional interaction between nucleosome assembly proteins and p300/CREB-binding protein family coactivators". Mol. Cell. Biol. 20 (23): 8933–43. doi:10.1128/MCB.20.23.8933-8943.2000. PMC 86548. PMID 11073993.
• Cicala C, Arthos J, Selig SM, et al. (2002). "HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication". Proc. Natl. Acad. Sci. U.S.A. 99 (14): 9380–5. Bibcode:2002PNAS...99.9380C. doi:10.1073/pnas.142287999. PMC 123149. PMID 12089333.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Rodriguez P, Ruiz MT, Price GB, Zannis-Hadjopoulos M (2005). "NAP-2 is part of multi-protein complexes in HeLa cells". J. Cell. Biochem. 93 (2): 398–408. doi:10.1002/jcb.20163. PMID 15368365. S2CID 12368640.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.