N6AMT1

N6AMT1
Identifiers
Aliases	N6AMT1, C21orf127, HEMK2, MTQ2, N6AMT, m.HsaHemK2P, PRED28, N-6 adenine-specific DNA methyltransferase 1 (putative), N-6 adenine-specific DNA methyltransferase 1, PrmC, KMT9
External IDs	OMIM: 614553 MGI: 1915018 HomoloGene: 5637 GeneCards: N6AMT1
Gene location (Human) Chr. Chromosome 21 (human) Band 21q21.3 Start 28,872,191 bp End 28,885,371 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 C3.3 Start 87,151,073 bp End 87,165,630 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube right adrenal gland ganglionic eminence ascending aorta left adrenal gland tibial nerve sural nerve right coronary artery left coronary artery canal of the cervix Top expressed in interventricular septum superior cervical ganglion hand yolk sac spinal ganglia proximal tubule left ventricle facial motor nucleus ascending aorta amygdala More reference expression data BioGPS n/a
Gene ontology Molecular function nucleic acid binding methyltransferase activity protein methyltransferase activity transferase activity protein binding S-adenosylmethionine-dependent methyltransferase activity Cellular component cytosol cytoplasm protein-containing complex Biological process positive regulation of cell growth protein methylation methylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29104 67768 Ensembl ENSG00000156239 ENSMUSG00000044442 UniProt Q9Y5N5 Q6SKR2 RefSeq (mRNA) NM_013240 NM_182749 NM_001159331 NM_026366 RefSeq (protein) NP_037372 NP_877426 NP_001152803 NP_080642 Location (UCSC) Chr 21: 28.87 – 28.89 Mb Chr 16: 87.15 – 87.17 Mb PubMed search
Wikidata
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N-6 adenine-specific DNA methyltransferase 1 is a protein that in humans is encoded by the N6AMT1 gene.

Function

The N6AMT1 gene encodes an N(6)-adenine-specific DNA methyltransferase. The encoded enzyme may be involved in the methylation of release factor I during translation termination. This enzyme is also involved in converting the arsenic metabolite monomethylarsonous acid to the less toxic dimethylarsonic acid. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Jul 2014]. N6AMT1 functions as a protein glutamine methyltransferase and is essential for mouse development (Liu et al., Mol. Cell. Biol. 2010).

Further reading

• Figaro S, Scrima N, Buckingham RH, Heurgué-Hamard V (July 2008). "HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1". FEBS Lett. 582 (16): 2352–6. doi:10.1016/j.febslet.2008.05.045. PMID 18539146. S2CID 38589664.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Ren X, Aleshin M, Jo WJ, Dills R, Kalman DA, Vulpe CD, Smith MT, Zhang L (June 2011). "Involvement of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicity". Environ. Health Perspect. 119 (6): 771–7. doi:10.1289/ehp.1002733. PMC 3114810. PMID 21193388.
• Harari F, Engström K, Concha G, Colque G, Vahter M, Broberg K (July 2013). "N-6-adenine-specific DNA methyltransferase 1 (N6AMT1) polymorphisms and arsenic methylation in Andean women". Environ. Health Perspect. 121 (7): 797–803. doi:10.1289/ehp.1206003. PMC 3702000. PMID 23665909.
• Chen X, Guo X, He P, Nie J, Yan X, Zhu J, Zhang L, Mao G, Wu H, Liu Z, Aga D, Xu P, Smith M, Ren X (January 2017). "Interactive Influence of N6AMT1 and As3MT Genetic Variations on Arsenic Metabolism in the Population of Inner Mongolia, China". Toxicol. Sci. 155 (1): 124–134. doi:10.1093/toxsci/kfw181. PMC 5216648. PMID 27637898.

Peng Liu,Song Nie, Bing Li,Zhong-Qiang Yang, Zhi-Mei Xu, Jian Fei, Chyuansheng Lin, Rong Zeng, and Guo-Liang Xu. Deficiency in a Glutamine-Specific Methyltransferase for Release Factor Causes Mouse Embryonic Lethality. MOLECULAR AND CELLULAR BIOLOGY, Sept. 2010, p. 4245–4253 Vol. 30, No. 17 0270-7306/10/

This article incorporates text from the United States National Library of Medicine, which is in the public domain.