Melanoma antigen family a, 8

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MAGEA8
Identifiers
AliasesMAGEA8, CT1.8, MAGE8, Melanoma antigen family a, 8, MAGE family member A8
External IDsOMIM: 300341 HomoloGene: 74553 GeneCards: MAGEA8
Orthologs
SpeciesHumanMouse
Entrez

4107

n/a

Ensembl

ENSG00000156009

n/a

UniProt

P43361

n/a

RefSeq (mRNA)

NM_005364
NM_001166400
NM_001166401

n/a

RefSeq (protein)

NP_001159872
NP_001159873
NP_005355

n/a

Location (UCSC)Chr X: 149.88 – 149.89 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Melanoma antigen family A, 8 is a protein that in humans is encoded by the MAGEA8 gene. [3]

Function

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Multiple alternatively spliced variants, encoding the same protein, have been identified.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000156009 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Entrez Gene: Melanoma antigen family A, 8". Retrieved 2014-08-25.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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