Mary Reilly (academic)

From WikiProjectMed
Jump to navigation Jump to search

Mary Reilly
Born
Belmullet, County Mayo, Ireland
Alma materUniversity College Dublin
Known forInherited neuropathies
Scientific career
InstitutionsNational Hospital for Neurology and Neurosurgery

Mary M. Reilly FRCP is an Irish neurologist who works at National Hospital for Neurology and Neurosurgery. She studies peripheral neuropathy. She is the President of the Association of British Neurologists.

Early life and education

Reilly studied medicine at University College Dublin, graduating in 1986.[1][2] She worked for a few years as a neurologist at St. Vincent's University Hospital, before joining Anita Harding at the National Hospital for Neurology and Neurosurgery in 1991.[1][3][4][5] Reilly has spoken of how much she admired her supervisor, and attributes her clinical interests to Harding.[6] Reilly earned her medical doctorate in 1996, focussing on familial amyloid polyneuropathy.[1][7][8] She completed her neurological training at Royal Free Hospital and Guy's Hospital, [1] training with P. K. Thomas and Richard Hughes.[9]

Career

At the National Hospital for Neurology and Neurosurgery Reilly specialises in inherited neuropathies.[10][11] She was made consultant neurologist in 1998[3] and a Fellow of the Royal College of Physicians in 2002.[4] She began to study neuromuscular disease, [12] in particular Charcot–Marie–Tooth disease.[13][14] In 2004, she found that Vitamin C could be used to improve symptoms in mouse models of CMT1A (Charcot–Marie–Tooth disease type 1A).[15] She established a randomized controlled trial with colleagues in Italy to evaluate the efficacy of Vitamin C on CMT1A.[15] The UK part of the trial consisted of 50 participants, and found that whilst Vitamin C is safe, it does not slow the progression of the disease.[15] Although the trial was not a success, it developed new neuropathy outcome measures.[15] Her research includes the identification of genes such as BICD2 and methionyl-tRNA synthetase (MARS);[10][16][17] she has already conducted functional analysis of IGHMBP2.[18]

Reilly works with Muscular Dystrophy UK on muscle-wasting conditions.[19] She has also worked on new biomarkers for disease progression.[20] CMT parents suffer from damaged motor nerves, which results in muscles weakening, and ultimately allows fat to accumulate in muscles; MRI outcome measures could monitor intramuscular fat accumulation, and detect muscle water changes that preceded fat accumulation.[20][21] Reilly identified that calf muscle fat friction maps are an outcome measure in patients with CMT1A, with calf muscle fat increased significantly in patients with CMT1A[22] She received a $1,000,000 grant from the Muscular Dystrophy Association to evaluate MRI protocols for monitoring changes in muscles from CMT.[23][21]

In 2010 Reilly was appointed Professor of Clinical Neurology at University College London.[24] She leads the Division of Clinical Neurology and Medical Research Council Centre for Neuromuscular Diseases.[25][26] With the MRC Centre for Neuromuscular Diseases and Muscular Dystrophy UK, Reilly runs an annual translational neuromuscular diseases meeting, which includes a patient day to discuss inherited neuropathies.[26] Along with CMT, Reilly has worked on hereditary sensory and autonomic neuropathies and carpal tunnel syndrome in inherited neuropathies.[27]

Reilly contributed to the 2013 Handbook of Clinical Neurology, [28] and wrote a chapter for the 2016 Springer Publishing collection Neuromuscular Disease: Case Studies from Queen Square.[29][30] Reilly has served as President of the British Peripheral Nerve Society and the International Peripheral Nerve Society.[31] In 2015 she was appointed President-elect of the Association of British Neurologists.[3] She became the first woman to take the role in 2017.[3]

References

  1. ^ a b c d "TREAT-NMD : Mary Reilly". www.treat-nmd.eu. Retrieved 23 January 2019.
  2. ^ "May 2017". UCD School of Medicine & Medical Science. Retrieved 23 January 2019.
  3. ^ a b c d UCL (24 March 2015). "Professor Mary Reilly is elected to be the first female President of the Association of British Neurologists in 83 years". UCL Queen Square Institute of Neurology. Retrieved 23 January 2019.
  4. ^ a b "May 2017". UCD School of Medicine & Medical Science. Retrieved 23 January 2019.
  5. ^ Reilly, Mary M.; King, Rosalind H. M. (1993). "Familial Amyloid Polyneuropathy". Brain Pathology. 3 (2): 165–176. doi:10.1111/j.1750-3639.1993.tb00741.x. ISSN 1750-3639. PMID 8293178. S2CID 22403075.
  6. ^ Cummins, Stephen (8 March 2018). "Remembering my first boss, the great Clinical Neurologist Anita Harding, on International Women's…". Medium. Retrieved 23 January 2019.
  7. ^ "Professor Mary M. Reilly Biography" (PDF). RCP. Retrieved 23 January 2019.
  8. ^ Reilly, M.M.; Adams, D.; Booth, D.R.; Davis, M.B.; Said, G.; Laubriat-Bianchin, M.; Pepys, M.B.; Thomas, P.K.; Harding, A.E. (1996). "Transthyretin gene analysis in European patients with suspected familial amyloid polyneuropathy". Neuromuscular Disorders. 6: 849–56. doi:10.1016/0960-8966(96)88834-1. ISSN 0960-8966. PMID 7655883. S2CID 36930164.
  9. ^ "Prof. Mary M Reilly, UK | RE-ACT Congress". www.react-congress.org. Retrieved 23 January 2019.
  10. ^ a b "Iris View Profile". iris.ucl.ac.uk. Retrieved 23 January 2019.
  11. ^ Reilly, Mary M. (1 April 2009). "Classification and diagnosis of the inherited neuropathies". Annals of Indian Academy of Neurology. 12 (2): 80–8. doi:10.4103/0972-2327.53075. ISSN 0972-2327. PMC 2812746. PMID 20142852.
  12. ^ Hanna, Michael G.; Reilly, Mary M. (1 December 2002). "Genetic neuromuscular disease". Journal of Neurology, Neurosurgery & Psychiatry. 73 (suppl 2): ii12–ii21. doi:10.1136/jnnp.73.suppl_2.ii12. ISSN 0022-3050. PMC 1765608. PMID 12536154.
  13. ^ Reilly, Mary M.; Evans, Matthew R. B.; Rossor, Alexander M. (1 June 2015). "A practical approach to the genetic neuropathies". Practical Neurology. 15 (3): 187–198. doi:10.1136/practneurol-2015-001095. ISSN 1474-7758. PMID 25898997.
  14. ^ Reilly, Mary M.; Murphy, Sinéad M.; Laurá, Matilde (2011). "Charcot-Marie-Tooth disease". Journal of the Peripheral Nervous System. 16 (1): 1–14. doi:10.1111/j.1529-8027.2011.00324.x. ISSN 1529-8027. PMID 21504497. S2CID 19868015.
  15. ^ a b c d "First clinical trial for Charcot Marie Tooth Disease". www.musculardystrophyuk.org. Retrieved 23 January 2019.
  16. ^ Consortium (INC), Inherited Neuropathy; Züchner, Stephan; Reilly, Mary M.; Antonellis, Anthony; Yang, Xiang-Lei; Speziani, Fiorella; Hadjivassilious, Marios; Yo-Tsen, Liu; Guo, Min (1 November 2013). "Exome sequencing identifies a significant variant in methionyl-tRNA synthetase (MARS) in a family with late-onset CMT2". J Neurol Neurosurg Psychiatry. 84 (11): 1247–1249. doi:10.1136/jnnp-2013-305049. ISSN 0022-3050. PMC 3796032. PMID 23729695.
  17. ^ Oates, Emily C.; Rossor, Alexander M.; Hafezparast, Majid; Gonzalez, Michael; Speziani, Fiorella; MacArthur, Daniel G.; Lek, Monkol; Cottenie, Ellen; Scoto, Mariacristina (6 June 2013). "Mutations in BICD2 Cause Dominant Congenital Spinal Muscular Atrophy and Hereditary Spastic Paraplegia". American Journal of Human Genetics. 92 (6): 965–973. doi:10.1016/j.ajhg.2013.04.018. ISSN 0002-9297. PMC 3675232. PMID 23664120.
  18. ^ Cottenie, Ellen; Kochanski, Andrzej; Jordanova, Albena; Bansagi, Boglarka; Zimon, Magdalena; Horga, Alejandro; Jaunmuktane, Zane; Saveri, Paola; Rasic, Vedrana Milic (6 November 2014). "Truncating and Missense Mutations in IGHMBP2 Cause Charcot-Marie Tooth Disease Type 2". American Journal of Human Genetics. 95 (5): 590–601. doi:10.1016/j.ajhg.2014.10.002. ISSN 0002-9297. PMC 4225647. PMID 25439726.
  19. ^ "Working in partnership - Muscular Dystrophy UK". www.musculardystrophyuk.org. Retrieved 23 January 2019.
  20. ^ a b Morrow, Jasper M; Sinclair, Christopher D J; Fischmann, Arne; Machado, Pedro M; Reilly, Mary M; Yousry, Tarek A; Thornton, John S; Hanna, Michael G (January 2016). "MRI biomarker assessment of neuromuscular disease progression: a prospective observational cohort study". The Lancet. Neurology. 15 (1): 65–77. doi:10.1016/S1474-4422(15)00242-2. ISSN 1474-4422. PMC 4672173. PMID 26549782.
  21. ^ a b Staff, M. D. A. (9 July 2018). "Critical Biomarker Development for CMT Receives $1 Million Boost from MDA". MDA. Retrieved 23 January 2019.
  22. ^ Reilly, Mary M.; Shy, Michael E.; Thornton, John S.; Nopoulos, Peggy; Hanna, Michael G.; Yousry, Tarek A.; Shah, Sachit; Thedens, Daniel; Sinclair, Christopher D. J. (18 September 2018). "Validation of MRC Centre MRI calf muscle fat fraction protocol as an outcome measure in CMT1A". Neurology. 91 (12): e1125–e1129. doi:10.1212/WNL.0000000000006214. ISSN 0028-3878. PMC 6161551. PMID 30120135.
  23. ^ "MDA Funds Development of a Critical Biomarker for Charcot Marie Tooth Disease". Muscular Dystrophy Association. 9 July 2018. Retrieved 23 January 2019.
  24. ^ "Mary Reilly, MD, FRCP, FRCPI | Neuropathy Commons". neuropathycommons.org. Retrieved 23 January 2019.
  25. ^ "Neuromuscular disease". www.uclh.nhs.uk. Retrieved 23 January 2019.
  26. ^ a b Muscular Dystrophy UK, Professor Mary Reilly talks about the development of treatments for Charcot-Marie-Tooth disease., retrieved 23 January 2019
  27. ^ "Mary M. Reilly - Head, Professor, Consultant of Neurology in London, England, United Kingdom | eMedEvents". www.emedevents.com. Retrieved 23 January 2019.
  28. ^ Murphy, Sinéad M.; Laurá, Matilde; Reilly, Mary M. (1 January 2013). "DNA testing in hereditary neuropathies". In Said, Gérard; Krarup, Christian (eds.). Chapter 12 - DNA testing in hereditary neuropathies. Peripheral Nerve Disorders. Vol. 115. Elsevier. pp. 213–232. doi:10.1016/B978-0-444-52902-2.00012-6. ISBN 9780444529022. PMID 23931782. {{cite book}}: |journal= ignored (help)
  29. ^ Manji, Hadi; Turner, Chris; Evans, Matthew R. B., eds. (2017). Neuromuscular Disease. doi:10.1007/978-1-4471-2389-7. ISBN 978-1-4471-2388-0.
  30. ^ Mahdi-Rogers, Mohamed; Laurá, Matilde; Reilly, Mary M. (2017), Manji, Hadi; Turner, Chris; Evans, Matthew R. B. (eds.), "A Woman Who Could Not Wear High Heels", Neuromuscular Disease : Case Studies from Queen Square, Springer London, pp. 3–6, doi:10.1007/978-1-4471-2389-7_1, ISBN 9781447123897
  31. ^ Editor (7 July 2017). "Interview with Mary Reilly - President of the Peripheral Nerve society (PNS)". eanpages - News Blog of the European Academy of Neurology. Retrieved 23 January 2019. {{cite web}}: |last= has generic name (help)
Retrieved from "https://mdwiki.org/wiki/Mary_Reilly_(academic)"