MIR187

MIR187
Identifiers
Aliases	MIR187, MIRN187, miR-187, miRNA187, microRNA 187
External IDs	OMIM: 612698 GeneCards: MIR187
Gene location (Human) Chr. Chromosome 18 (human) Band 18q12.2 Start 35,904,818 bp End 35,904,926 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of stomach left ventricle monocyte blood salivary gland minor salivary glands subcutaneous adipose tissue skin of abdomen dorsolateral prefrontal cortex endometrium n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 406963 n/a Ensembl ENSG00000207797 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 18: 35.9 – 35.9 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

MicroRNA 187 is a protein that in humans is encoded by the MIR187 gene.

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA.

Further reading

• Rossato M, Curtale G, Tamassia N, Castellucci M, Mori L, Gasperini S, Mariotti B, De Luca M, Mirolo M, Cassatella MA, Locati M, Bazzoni F (November 2012). "IL-10-induced microRNA-187 negatively regulates TNF-α, IL-6, and IL-12p40 production in TLR4-stimulated monocytes" (PDF). Proceedings of the National Academy of Sciences of the United States of America. 109 (45): E3101-10. doi:10.1073/pnas.1209100109. PMC 3494907. PMID 23071313.
• Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP (March 2003). "Vertebrate microRNA genes". Science. 299 (5612): 1540. doi:10.1126/science.1080372. PMID 12624257. S2CID 37750545.
• Dostie J, Mourelatos Z, Yang M, Sharma A, Dreyfuss G (February 2003). "Numerous microRNPs in neuronal cells containing novel microRNAs". RNA. 9 (2): 180–6. doi:10.1261/rna.2141503. PMC 1370383. PMID 12554860.
• Chao A, Lin CY, Lee YS, Tsai CL, Wei PC, Hsueh S, Wu TI, Tsai CN, Wang CJ, Chao AS, Wang TH, Lai CH (February 2012). "Regulation of ovarian cancer progression by microRNA-187 through targeting Disabled homolog-2". Oncogene. 31 (6): 764–75. doi:10.1038/onc.2011.269. PMID 21725366.
• Mulrane L, Madden SF, Brennan DJ, Gremel G, McGee SF, McNally S, Martin F, Crown JP, Jirström K, Higgins DG, Gallagher WM, O'Connor DP (December 2012). "miR-187 is an independent prognostic factor in breast cancer and confers increased invasive potential in vitro". Clinical Cancer Research. 18 (24): 6702–13. doi:10.1158/1078-0432.CCR-12-1420. PMID 23060431.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.