MFRP

MFRP
Identifiers
Aliases	MFRP, MCOP5, NNO2, RD6, membrane frizzled-related protein, CTRP5
External IDs	OMIM: 606227 MGI: 2385957 HomoloGene: 12866 GeneCards: MFRP
Gene location (Human) Chr. Chromosome 11 (human) Band 11q23.3 Start 119,338,942 bp End 119,346,705 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9 A5.1|9 24.6 cM Start 44,013,026 bp End 44,020,484 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon hippocampus proper placenta corpus callosum substantia nigra hypothalamus urinary bladder right adrenal gland temporal lobe amygdala Top expressed in secondary oocyte hippocampus proper lens cerebellum cerebellar cortex morula kidney superior frontal gyrus lip uterus More reference expression data BioGPS n/a
Gene ontology Molecular function molecular function Cellular component apical plasma membrane integral component of membrane plasma membrane membrane Biological process visual perception eye photoreceptor cell development retina development in camera-type eye embryo development ending in birth or egg hatching Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83552 259172 Ensembl ENSG00000235718 ENSMUSG00000034739 UniProt Q9BY79 Q8K480 RefSeq (mRNA) NM_031433 NM_001190314 NM_147126 RefSeq (protein) NP_113621 NP_001177243 NP_667337 Location (UCSC) Chr 11: 119.34 – 119.35 Mb Chr 9: 44.01 – 44.02 Mb PubMed search
Wikidata
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Membrane frizzled-related protein is a protein that in humans is encoded by the MFRP gene.

Further reading

• Metlapally R, Li YJ, Tran-Viet KN, et al. (2008). "Common MFRP sequence variants are not associated with moderate to high hyperopia, isolated microphthalmia, and high myopia". Mol. Vis. 14: 387–93. PMC 2268852. PMID 18334955.
• Ayala-Ramirez R, Graue-Wiechers F, Robredo V, et al. (2007). "A new autosomal recessive syndrome consisting of posterior microphthalmos, retinitis pigmentosa, foveoschisis, and optic disc drusen is caused by a MFRP gene mutation". Mol. Vis. 12: 1483–9. PMID 17167404.
• Yang L, Yamasaki K, Shirakata Y, et al. (2006). "Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes". J. Dermatol. Sci. 42 (2): 111–9. doi:10.1016/j.jdermsci.2005.12.011. PMID 16442268.
• Pauer GJ, Xi Q, Zhang K, et al. (2006). "Mutation screen of the membrane-type frizzled-related protein (MFRP) gene in patients with inherited retinal degenerations". Ophthalmic Genet. 26 (4): 157–61. doi:10.1080/13816810500374425. PMID 16352475. S2CID 43634962.
• Mandal MN, Heckenlively JR, Burch T, et al. (2005). "Sequencing arrays for screening multiple genes associated with early-onset human retinal degenerations on a high-throughput platform". Invest. Ophthalmol. Vis. Sci. 46 (9): 3355–62. doi:10.1167/iovs.05-0007. PMID 16123440.
• Sundin OH, Leppert GS, Silva ED, et al. (2005). "Extreme hyperopia is the result of null mutations in MFRP, which encodes a Frizzled-related protein". Proc. Natl. Acad. Sci. U.S.A. 102 (27): 9553–8. Bibcode:2005PNAS..102.9553S. doi:10.1073/pnas.0501451102. PMC 1172243. PMID 15976030.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Hayward C, Shu X, Cideciyan AV, et al. (2004). "Mutation in a short-chain collagen gene, CTRP5, results in extracellular deposit formation in late-onset retinal degeneration: a genetic model for age-related macular degeneration". Hum. Mol. Genet. 12 (20): 2657–67. doi:10.1093/hmg/ddg289. PMID 12944416.