MAML1

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MAML1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMAML1, Mam-1, Mam1, mastermind like transcriptional coactivator 1
External IDsOMIM: 605424 MGI: 1890504 HomoloGene: 8845 GeneCards: MAML1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014757

NM_175334

RefSeq (protein)

NP_055572

NP_780543
NP_001388483

Location (UCSC)Chr 5: 179.73 – 179.78 MbChr 11: 50.15 – 50.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mastermind-like protein 1 is a protein that in humans is encoded by the MAML1 gene.[5][6][7]

Function

This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.[7]

Details on the activity of the N-terminal domain of Mastermind-like protein 1 may be found under MamL-1.

Interactions

MAML1 has been shown to interact with EP300[8][9] and NOTCH1.[5][10]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000161021 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050567 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD (Dec 2000). "MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors". Nat Genet. 26 (4): 484–9. doi:10.1038/82644. PMID 11101851. S2CID 23335042.
  6. ^ Kitagawa M, Oyama T, Kawashima T, Yedvobnick B, Kumar A, Matsuno K, Harigaya K (Jun 2001). "A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters". Mol Cell Biol. 21 (13): 4337–46. doi:10.1128/MCB.21.13.4337-4346.2001. PMC 87094. PMID 11390662.
  7. ^ a b "Entrez Gene: MAML1 mastermind-like 1 (Drosophila)".
  8. ^ Wallberg AE, Pedersen K, Lendahl U, Roeder RG (Nov 2002). "p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro". Mol. Cell. Biol. 22 (22): 7812–9. doi:10.1128/MCB.22.22.7812-7819.2002. PMC 134732. PMID 12391150.
  9. ^ Fryer CJ, Lamar E, Turbachova I, Kintner C, Jones KA (Jun 2002). "Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex". Genes Dev. 16 (11): 1397–411. doi:10.1101/gad.991602. PMC 186317. PMID 12050117.
  10. ^ Wu L, Sun T, Kobayashi K, Gao P, Griffin JD (Nov 2002). "Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors". Mol. Cell. Biol. 22 (21): 7688–700. doi:10.1128/MCB.22.21.7688-7700.2002. PMC 135662. PMID 12370315.

Further reading