Lupus pernio

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Lupus pernio
Cutaneous lesions of sarcoidosis (lupus pernio). Red-to-purple indurated plaques and nodules affecting the nose and cheeks.

Lupus pernio is a chronic raised indurated (hardened) lesion of the skin, often purplish in color. It is seen on the nose, ears, cheeks, lips, and forehead. It is pathognomonic of sarcoidosis.[1]: 701  The name "lupus pernio" is a misnomer, as microscopically this disease shows granulomatous infiltration and does not have features of either lupus or pernio.[2]

Lupus pernio is associated with poor outcomes and lower rates of resolution.

Lupus pernio and erythema nodosum are cutaneous manifestation of sarcoidosis, may suggest this disease as a cause of an associated dilated cardiomyopathy, especially with heart block, intraventricular conduction delay, or ventricular tachycardia.

See also


  1. James, William D.; Berger, Timothy G.; et al. (2011). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 978-1-4377-0314-6.
  2. Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.

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