Locus suicide recombination
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Locus suicide recombination (LSR) constitutes a variant form of class switch recombination that eliminates all immunoglobulin heavy chain constant genes.[1] It thus terminates immunoglobulin and B-cell receptor (BCR) expression in B-lymphocytes and results in B-cell death since survival of such cells requires BCR expression. This process is initiated by the enzyme activation-induced deaminase upon B-cell activation. LSR is thus one of the pathways that can result into activation-induced cell death in the B-cell lineage.[2]
References
- ^ Acton, Q.A. (2013). Immunoglobulins—Advances in Research and Application: 2013 Edition. ScholarlyEditions. p. 866. ISBN 978-1-4816-8886-4. Retrieved 26 October 2018.
- ^ Peron, S.; Laffleur, B.; Denis-Lagache, N.; Cook-Moreau, J.; Tinguely, A.; Delpy, L.; Denizot, Y.; Pinaud, E.; Cogne, M. (26 April 2012). "AID-Driven Deletion Causes Immunoglobulin Heavy Chain Locus Suicide Recombination in B Cells". Science. 336 (6083). American Association for the Advancement of Science (AAAS): 931–934. Bibcode:2012Sci...336..931P. doi:10.1126/science.1218692. ISSN 0036-8075. PMID 22539552. S2CID 1513560.