List of people from Lancaster County, Pennsylvania

This is a list of notable people who were born, or who have lived in Lancaster County, Pennsylvania.

• William Addams (1777–1858), U.S. representative
• David Hayes Agnew (1818–1892), surgeon
• Chas Alecxih, NFL defensive lineman
• Andy Baldwin, U.S. Navy lieutenant and physician, bachelor of season 10 of The Bachelor
• James Buchanan (1791–1868), 15th President of the United States
• Thomas Burch (1778–1849), Methodist circuit rider
• Simon Cameron (1799–1889), Secretary of War
• Miles B. Carpenter (1889–1985), sculptor
• Diane Cluck, singer-songwriter
• Lewis Cohen, playing card manufacturer
• Adam Cole, professional wrestler
• Michael Deibert, journalist, author
• Charles Demuth (1883–1935), painter
• Jon Dough (born Chet Anuszak), born in Lancaster
• William Duchman (1809–1881), Wisconsin state legislator and sawmill operator
• Gretchen Egolf, actress, sister of Tristan Egolf
• Tristan Egolf (1971–2005), novelist, author, activist
• Andrew Ellicott (1754–1820), surveyor
• Michael Erlewine, founder of All Media Guide (AMG)
• Andrew J. Feustel, NASA astronaut
• FFH, Contemporary Christian band
• Robert Fulton (1765–1815), engineer, inventor, creator of Clermont steamboat
• Jim Furyk, professional golfer
• Cam Gallagher, professional baseball player
• Gene Garber, Major League Baseball relief pitcher
• Jennifer Gareis, actress and 1994 Miss New York
• Lewis E. Gettle, Wisconsin State Assemblyman and lawyer
• Matt Greiner, drummer of metalcore band August Burns Red
• Jonathan Groff, actor and singer who originated role of "Melchior" in the Broadway musical Spring Awakening
• Klaus Grutzka (1923–2011), industrial artist
• Edward Hand (1744–1802), physician, farmer, congressman, general officer in Continental Army during American Revolutionary War
• Tom Herr, MLB second baseman
• Milton S. Hershey (1857–1945), chocolatier, founder of the Hershey Company
• S. Dale High, chairman of High Industries
• Rev.Earl Honaman (1904–1982), Suffragan Bishop of the Episcopal Diocese of Central Pennsylvania
• The Innocence Mission, band from Lancaster (performed the hit song "Bright as Yellow")
• Travis Jankowski, professional baseball player
• Taylor Kinney, actor and model
• Maria Louise Kirk, painter and illustrator
• Dan Kreider, NFL fullback
• Floyd Landis, professional road bicycle racer
• D. Ross Lederman (1894–1972), film director
• Frank B. McClain (1864–1925), Mayor of Lancaster(24th), Pennsylvania, Lt Gov State of Pennsylvania (1914)
• Alexander McNair, first Governor of Missouri
• Thomas Mifflin, merchant, politician, governor of Pennsylvania
• Anna Balmer Myers, author of early 20th-century novels centered in Lancaster County
• Clarence Charles Newcomer (1923–2005), United States federal judge
• Karin Olah (born 1977), contemporary painter, collage, and fiber artist
• Amish Outlaws, cover band
• Nguyen Chanh Thi (1923–2007), Army of the Republic of Vietnam general, retired to Lancaster
• John Parrish, MLB relief pitcher
• Barry Pearl (born 1950), actor
• Molly Picon (1898–1992), actress, died in Lancaster
• Peter Reesor (1775-1854) along with family including father Christian Reesor (1747-1806) moved to settled in what is now Markham, Ontario in 1804
• John F. Reynolds (1820–1863), U.S. Army major general, American Civil War
• Charles Carl Roberts (1973–2006), perpetrator of the West Nickel Mines School shooting
• Keegan Rosenberry, professional soccer player, Philadelphia Union
• Brad Rutter, Jeopardy! champion
• Theodore Emanuel Schmauk (1860–1920), Lutheran theologian, educator
• Frank H. Shaw (1882–1950), civil engineer
• Pete Snyder, founder of New Media Strategies
• Thaddeus Stevens (1792–1868), U.S. representative, Republican
• John Stockton, Michigan territorial legislator
• Daniel B. Strickler (1897–1992), U.S. Army lieutenant general, lieutenant governor
• Bruce Sutter, Hall of Fame pitcher
• William G. Thompson, mayor of Detroit, Michigan 1881-83
• Julian Valentin, professional soccer player
• Zarek Valentin, professional soccer player
• Junior Vasquez, New York City club DJ, remixer, producer
• Robert S. Walker, U.S. representative, Republican
• James Weaver, California Angels pitcher
• Andrew Wenger, professional soccer player
• Suzanne Westenhoefer, comedian
• William Whipper (1804–1876), African American businessman, activist
• Charlotte White (1782–1863), first unmarried American female missionary, arrived in India in 1816
• Marianne Wiggins, author
• Kristen Wiig, actress and comedian
• Michael Willis, character actor
• Richard Winters, U.S. Army paratrooper portrayed in Stephen Ambrose's 1992 book and miniseries Band of Brothers