List of American musicians of Armenian descent

This is a list of famous Armenian American musicians. For other famous Armenian Americans, see List of Armenian Americans.

• Adiss Harmandian – pop singer
• Alan Hovhaness – among the most prolific of 20th-century composers
• Albert Asriyan – violinist, composer, arranger and band leader
• Anahid Ajemian – violinist
• Angel Deradoorian – experimental rock singer-songwriter, multi-instrumentailist, producer. She is known for her work with Dirty Projectors
• Ani Kavafian – classical violinist
• Anita Darian - soprano - vocalist - The Lion Sleeps Tonight
• Ara Babajian – drummer and member of Leftöver Crack and The Slackers
• Ara Berberian – operatic bass singer
• Ara Dinkjian – oudist
• Armand Tokatyan – operatic tenor
• Armen Anassian – violinist
• Armen Chakmakian – composer
• Armen Donelian – jazz pianist
• Armen Nalbandian – jazz pianist, and composer
• Armen Ra – artist and performer
• Armenian Jazz Sextet – group playing Armenian music
• Arto Tunçboyacıyan - musician
• Beatrice Ohanessian – pianist, notable for being Iraq's first concert pianist and first female composer
• Berj Zamkochian – organist
• Bruce Nazarian – Producer, Recording Artist, Studio Musician, Composer, Lyricist. Two Billboard chart appearances as lead vocalist.
• Cathy Berberian – composer, mezzo-soprano singer, and vocalist
• Charles Amirkhanian – composer
• Cher – pop singer-songwriter
• Clint Bajakian – video game composer and musician
• Daron Malakian – singer-songwriter, multi-instrumentalist, and record producer, lead guitarist, songwriter, and occasional vocalist of the Grammy Award-winning metal band System of a Down. He placed 30th in Guitar World's List of The 100 Greatest Heavy Metal Guitarists of All Time
• Dennis Agajanian – Christian musician
• Derek Sherinian – among the elite rock keyboardists in the world
• Dianne Goolkasian Rahbee – classical composer
• Duane Betts – singer-songwriter and guitarist
• Edward Manukyan – composer
• Eleanor Barooshian – singer-songwriter
• Eve Beglarian – composer
• Grikor Suni – composer
• Gerard Jirayr Svazlian – violinist
• Greg Jehanian – bassist and backing vocalist, member of indie rock band mewithoutYou
• Haig Mardirosian – concert organist, composer, and conductor
• Haroutioun Hovanes Chakmakjian – composer
• Harry Babasin – jazz bassist
• Ida Kavafian – classical violinist and violist
• Ivan Galamian – influential violin teacher of the twentieth century
• Jeff Atmajian – arranger and orchestrator
• Jeff Manookian - composer and conductor
• John Berberian – oudist
• John Dolmayan – songwriter, drummer, and member of System of a Down
• John Herald – folk and bluegrass songwriter, solo and studio musician, and one-time member of The Greenbriar Boys trio
• Kallen Esperian – lyric soprano
• Karine Poghosyan - pianist
• Kim Kashkashian – violist
• Konstantin Orbelyan, Jr. – pianist, and conductor of State Academic Chamber Orchestra of Russia
• Levon Ambartsumian – violinist and conductor
• Lucine Amara- soprano
• Maro Ajemian – pianist
• Michael Gulezian – composer and Fingerstyle guitarist
• Michael Omartian – singer-songwriter, keyboardist, and music producer
• Ontronik Khachaturian – singer-songwriter, multi-instrumentalist, record producer, and drummer member of System of a Down
• Paul Motian – jazz drummer, percussionist and composer of Armenian extraction
• Peter Dombourian – music educator, and conductor
• Raffi Besalyan - pianist
• Richard Hagopian – oudist, violinist, and clarinet
• Richard Yardumian – classical music composer
• Ross Bagdasarian, Sr. – pianist, singer, and songwriter
• Roupen Altiparmakian- violinist and oudist
• Şahan Arzruni – pianist, composer, and ethnomusicologist
• Serj Tankian – rock singer–songwriter, multi-instrumentalist, record producer, poet, philosopher and a political activist, best known as the lead vocalist, songwriter, keyboardist, and occasionally live rhythm guitarist of the Grammy Award-winning rock band, System of a Down
• Shavo Odadjian – songwriter, multi-instrumentalist, music video director/editor, music producer, and artist/painter, best known as the bassist and occasional songwriter of the Grammy Award-winning rock band, System of a Down
• Sib Hashian – drummer and member of the rock band Boston
• Stephanie Nakasian – jazz vocalist and voice teacher
• Tamar Kaprelian – singer
• Tonio K – singer/songwriter