Linoleate 9S-lipoxygenase

Linoleate 9S-lipoxygenase (EC 1.13.11.58, 9-lipoxygenase, 9S-lipoxygenase, linoleate 9-lipoxygenase, LOX1 (gene), 9S-LOX) is an enzyme with systematic name linoleate:oxygen 9S-oxidoreductase.^[1]^[2]^[3]^[4] This enzyme catalyses the following chemical reaction

\rightleftharpoons

(9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate

Linoleate 9S-lipoxygenase contains nonheme iron.

References

^ Vellosillo T, Martínez M, López MA, Vicente J, Cascón T, Dolan L, Hamberg M, Castresana C (March 2007). "Oxylipins produced by the 9-lipoxygenase pathway in Arabidopsis regulate lateral root development and defense responses through a specific signaling cascade". The Plant Cell. 19 (3): 831–46. doi:10.1105/tpc.106.046052. PMC 1867370. PMID 17369372.
^ Boeglin WE, Itoh A, Zheng Y, Coffa G, Howe GA, Brash AR (November 2008). "Investigation of substrate binding and product stereochemistry issues in two linoleate 9-lipoxygenases". Lipids. 43 (11): 979–87. doi:10.1007/s11745-008-3230-1. PMC 4710486. PMID 18795358.
^ Andreou AZ, Hornung E, Kunze S, Rosahl S, Feussner I (March 2009). "On the substrate binding of linoleate 9-lipoxygenases". Lipids. 44 (3): 207–15. doi:10.1007/s11745-008-3264-4. PMID 19037675. S2CID 4004916.
^ Bannenberg G, Martínez M, Hamberg M, Castresana C (February 2009). "Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana". Lipids. 44 (2): 85–95. doi:10.1007/s11745-008-3245-7. PMID 18949503. S2CID 19170797.

v t e Oxidoreductases: monooxygenases (EC 1.13)
1.13.11: two atoms of oxygen	lipoxygenase: Arachidonate 5-lipoxygenase Arachidonate 12-lipoxygenase/ALOX12 Arachidonate 8-lipoxygenase Arachidonate 15-lipoxygenase/ALOX15 Linoleate 11-lipoxygenase other dioxygenase: Catechol dioxygenase Homogentisate 1,2-dioxygenase Cysteine dioxygenase 4-Hydroxyphenylpyruvate dioxygenase Indoleamine 2,3-dioxygenase Chlorite dismutase
1.13.12: one atom of oxygen	Firefly luciferase
1.13.99: other	Inositol oxygenase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)