Linda Columbus

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Linda Marie Columbus
Alma materScripps Research Institute
University of California, Los Angeles
Smith College
Scientific career
InstitutionsUniversity of Virginia
ThesisInvestigating backbone and side chain dynamics of alpha-helices in the nanosecond regime with site-directed spin labeling (2001)
WebsiteColumbus Lab

Linda Columbus is an American chemist who is Professor of Chemistry and Molecular Physiology at the University of Virginia. Her research considers the structure-function properties of membrane proteins.

Early life and education

Columbus was born to young parents, neither of whom were educated beyond high school, and grew up in New Hampshire.[1] Columbus was an undergraduate student at Smith College and moved to the University of California, Los Angeles, for graduate research.[2] Her doctoral research with Prof. Wayne L. Hubbell involved the use of spin labelling to understand the backbone and side chain dynamics of α-helices in the nanosecond regime.[3] After earning her doctorate, Columbus joined The Scripps Research Institute as an NIH research fellow.[4]

Research and career

In 2013, Columbus joined the University of Virginia as an assistant professor.[1] She was promoted to full professor in 2019.[citation needed] She studies the membrane proteins that comprise around one quarter of a proteome. These membrane proteins are involved with information transfer across lipid bilayers, and are used as drug targets.[5] Columbus investigates the membrane proteins that mediate interactions between hosts and bacterial pathogens.[4][6] To study the structures of the membrane proteins involved in cellular invasion by bacterial pathogens, Columbus makes use of site-directed spin labelling and nuclear magnetic resonance.[4][7]

Awards and honors

Selected publications

  • Linda Columbus; Wayne L Hubbell (1 June 2002). "A new spin on protein dynamics". Trends in Biochemical Sciences. 27 (6): 288–295. doi:10.1016/S0968-0004(02)02095-9. ISSN 0968-0004. PMID 12069788. Wikidata Q34691381.
  • L Columbus; T Kálai; J Jekö; K Hideg; W L Hubbell (1 April 2001). "Molecular motion of spin labeled side chains in alpha-helices: analysis by variation of side chain structure". Biochemistry. 40 (13): 3828–3846. doi:10.1021/BI002645H. ISSN 0006-2960. PMID 11300763. Wikidata Q43573920.
  • Jan Lipfert; Linda Columbus; Vincent B Chu; Scott A Lesley; Sebastian Doniach (9 October 2007). "Size and shape of detergent micelles determined by small-angle X-ray scattering". The Journal of Physical Chemistry B. 111 (43): 12427–12438. doi:10.1021/JP073016L. ISSN 1520-6106. PMID 17924686. Wikidata Q44871938.

References

  1. ^ a b "Linda Columbus". The Biophysical Society. Retrieved 2022-04-20.
  2. ^ "Our People". Columbus Lab. Retrieved 2022-04-20.
  3. ^ Columbus, Linda Marie (2001). Investigating backbone and side chain dynamics of [alpha]-helices in the nanosecond regime with site-directed spin labeling. OCLC 732921756.
  4. ^ a b c "Department of Chemistry". chemistry.as.virginia.edu. Retrieved 2022-04-20.
  5. ^ "Dr. Linda Columbus, University of Virginia". chemistry.umbc.edu. Retrieved 2022-04-20.
  6. ^ "World Changers: Faculty members receive Commonwealth's highest honor". Virginia Magazine. Retrieved 2022-04-20.
  7. ^ "RESEARCH". Columbus Lab. Retrieved 2022-04-20.
  8. ^ "NSF Award Search: Award # 0845668 - CAREER: An Innovative Study of Membrane Protein - Detergent Interactions". www.nsf.gov. Retrieved 2022-04-20.
  9. ^ Advancement, Research Corporation for Science. "CSC Awards". Research Corporation for Science Advancement. Retrieved 2022-04-20.
  10. ^ "CMCP Linda Columbus has received the 2014 Outstanding Faculty Award". Center for Membrane and Cell Physiology. 2014-01-24. Retrieved 2022-04-20.
  11. ^ "Past Council | Biophysical Society". www.biophysics.org. Retrieved 2022-04-20.
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