LTN1

LTN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J92
Identifiers
Aliases	LTN1, C21orf10, C21orf98, RNF160, ZNF294, listerin E3 ubiquitin protein ligase 1
External IDs	OMIM: 613083 MGI: 1926163 HomoloGene: 32272 GeneCards: LTN1
Gene location (Human)
Chr.	Chromosome 21 (human)
End	28,992,956 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	87,229,500 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; biceps brachii; ; endothelial cell; ; right ventricle; ; jejunal mucosa; ; corpus epididymis; ; Achilles tendon; ; seminal vesicula; ; caput epididymis; ; oral cavity;
	Top expressed in
	cumulus cell; ; seminiferous tubule; ; lacrimal gland; ; substantia nigra; ; pineal gland; ; parotid gland; ; spermatid; ; seminal vesicula; ; ascending aorta; ; aortic valve;
	More reference expression data
	n/a
Gene ontology
Molecular function	zinc ion binding; protein binding; metal ion binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity; transferase activity; ribosomal large subunit binding;
Cellular component	cytosol; RQC complex;
Biological process	protein ubiquitination; protein autoubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process; rescue of stalled ribosome; ribosome-associated ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	26046
	78913
	ENSG00000198862
	ENSMUSG00000052299
	O94822
	Q6A009
	NM_015565; NM_001320766
	NM_001081068
	NP_001307695; NP_056380
	NP_001074537
	Wikidata
View/Edit Human	View/Edit Mouse

Listerin E3 ubiquitin protein ligase 1 (LTN1), otherwise known as listerin, is a protein that in humans is encoded by the LTN1 gene.^[5]

Function

Like most RING finger proteins, listerin functions as an E3 ubiquitin ligase.^[6] Listerin is a component of the ribosome quality control complex.^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198862 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052299 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Listerin E3 ubiquitin protein ligase 1".
^ Chu J, Hong NA, Masuda CA, Jenkins BV, Nelms KA, Goodnow CC, Glynne RJ, Wu H, Masliah E, Joazeiro CA, Kay SA (February 2009). "A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration". Proceedings of the National Academy of Sciences of the United States of America. 106 (7): 2097–103. doi:10.1073/pnas.0812819106. PMC 2650114. PMID 19196968.
^ Shao S, Brown A, Santhanam B, Hegde RS (February 2015). "Structure and assembly pathway of the ribosome quality control complex". Molecular Cell. 57 (3): 433–44. doi:10.1016/j.molcel.2014.12.015. PMC 4321881. PMID 25578875.
^ Shao S, von der Malsburg K, Hegde RS (June 2013). "Listerin-dependent nascent protein ubiquitination relies on ribosome subunit dissociation". Molecular Cell. 50 (5): 637–48. doi:10.1016/j.molcel.2013.04.015. PMC 3719020. PMID 23685075.