LCORL

LCORL
Identifiers
Aliases	LCORL, MLR1, ligand dependent nuclear receptor corepressor like
External IDs	OMIM: 611799 MGI: 2651932 HomoloGene: 82325 GeneCards: LCORL
Gene location (Human) Chr. Chromosome 4 (human) Band 4p15.31 Start 17,841,199 bp End 18,021,876 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 B3 Start 45,697,181 bp End 45,857,615 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell sperm jejunal mucosa visceral pleura tibia parietal pleura pancreatic ductal cell ganglionic eminence germinal epithelium retinal pigment epithelium Top expressed in ventromedial nucleus habenula spermatocyte barrel cortex pineal gland trigeminal ganglion cumulus cell sciatic nerve parotid gland submandibular gland More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process regulation of transcription by RNA polymerase II regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 254251 209707 Ensembl ENSG00000178177 ENSMUSG00000015882 UniProt Q8N3X6 Q3U285 RefSeq (mRNA) NM_001166139 NM_153686 NM_001163073 NM_172153 NM_178142 NM_001359871 NM_001359872 NM_001359873 NM_001359874 RefSeq (protein) NP_001159611 NP_710153 NP_001352587 NP_001352588 NP_001352589 NP_001352590 NP_001352591 NP_001352592 NP_001352594 NP_001156545 NP_742165 NP_835278 NP_001346800 NP_001346801 NP_001346802 NP_001346803 Location (UCSC) Chr 4: 17.84 – 18.02 Mb Chr 5: 45.7 – 45.86 Mb PubMed search
Wikidata
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Ligand dependent nuclear receptor corepressor like is a protein that in humans is encoded by the LCORL gene.

Function

This gene encodes a transcription factor that appears to function in spermatogenesis. Polymorphisms in this gene are associated with measures of skeletal frame size and adult height. Alternative splicing results in multiple transcript variants.

Further reading

• Kunieda T, Park JM, Takeuchi H, Kubo T (2003). "Identification and characterization of Mlr1,2: two mouse homologues of Mblk-1, a transcription factor from the honeybee brain(1)". FEBS Lett. 535 (1–3): 61–5. doi:10.1016/s0014-5793(02)03858-9. PMID 12560079. S2CID 83745027.
• Sovio, U; Bennett, AJ; Millwood, IY; Molitor, J; O'Reilly, PF; Timpson, NJ; Kaakinen, M; Laitinen, J; Haukka, J; Pillas, D; Tzoulaki, I; Molitor, J; Hoggart, C; Coin, LJ; Whittaker, J; Pouta, A; Hartikainen, AL; Freimer, NB; Widen, E; Peltonen, L; Elliott, P; McCarthy, MI; Jarvelin, MR (March 2009). "Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966". PLOS Genetics. 5 (3): e1000409. doi:10.1371/journal.pgen.1000409. PMC 2646138. PMID 19266077.
• Soranzo N, Rivadeneira F, Chinappen-Horsley U, Malkina I, Richards JB, Hammond N, Stolk L, Nica A, Inouye M, Hofman A, Stephens J, Wheeler E, Arp P, Gwilliam R, Jhamai PM, Potter S, Chaney A, Ghori MJ, Ravindrarajah R, Ermakov S, Estrada K, Pols HA, Williams FM, McArdle WL, van Meurs JB, Loos RJ, Dermitzakis ET, Ahmadi KR, Hart DJ, Ouwehand WH, Wareham NJ, Barroso I, Sandhu MS, Strachan DP, Livshits G, Spector TD, Uitterlinden AG, Deloukas P (2009). "Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size". PLOS Genet. 5 (4): e1000445. doi:10.1371/journal.pgen.1000445. PMC 2661236. PMID 19343178.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.