Kathy Niakan

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Kathy Niakan
Niakan as Charles Wright Academy Alum of the Year in 2016
Born1977
Memphis, Tennessee, USA [1]
NationalityAmerican [1]
EducationPhD in stem cell research
Alma materUniversity of Washington, University of California, Los Angeles
Known forOne of the 100 most influential people in the world by Time magazine in April 2016.[2]
Scientific career
FieldsStem cell biology
InstitutionsFrancis Crick Institute

Kathy Niakan is a developmental biologist, working in human developmental and stem cell biology. In 2016 she became the first scientist in the world to gain regulatory approval to edit the genomes of human embryos for research.[3]

Niakan was named as one of the 100 most influential people in the world by Time magazine in April 2016.[2]

Biography

Kathy Niakan obtained a BSc in cell and molecular biology and a BA in English literature from the University of Washington. In 2005, Niakan obtained her PhD in stem cell and developmental biology from the University of California, Los Angeles, where she worked in the laboratory of Edward McCabe.[4] She went on to be a research fellow with Kevin Eggan at Harvard University, working with human and mouse stem cells to study human embryogenesis and cell potency. She then moved to the University of Cambridge Anne McLaren Laboratory for Stem Cell Biology in the Cambridge Biomedical Campus where she continued to investigate the molecular basis of early cell development in humans and mice.[5] In 2013, Niakan became a group leader at the MRC National Institute for Medical Research (NIMR) in London. Since 2015, she has been a group leader at the Francis Crick Institute,[4] the successor institute to the NIMR.[6]

She was a finalist in the inaugorary UK Blavatnik Awards for Young Scientists in 2019.[7]

In 2021, Professor Kathy Niakan was appointed as an honorary group leader in the Epigenetics research programme as part of the Babraham Institute. The Babraham Institute pioneers world-changing scientific developments, and focuses on cellular signalling, gene regulation, immunology, and the impact of epigenetic regulation at different stages of life. This new appointment and leadership position will hopefully allow Kathy to collaborate with others in her field and continue vital research.[8]

Research

At the Francis Crick Institute she is investigating the mechanisms of lineage specification in human embryos and stem cells.[5]

In February 2016 Niakan was given the go-ahead by the UK Human Fertilisation and Embryology Authority to genetically modify human embryos. The embryos were to be destroyed after seven days.[9] She planned to use the CRISPR technique to answer questions like what genetic faults cause some women to miscarry, what causes infertility and what is crucial for a healthy embryo.[5][10] In 2017 her lab published the first major study using CRISPR-Cas9 in human embryos in Nature, demonstrating that the transcription factor Oct4 is essential for fetal development.[11]

In addition to her pioneering research, Professor Niakan has engaged with policy makers, funders and the public to provide expert advice on genome editing.

References

  1. ^ a b "Dr Kathy Niakan honoured by TIME magazine".
  2. ^ a b Doudna, Jennfer (2016-04-21). "Kathy Niakan". The World’s 100 Most Influential People. Time Magazine. Retrieved 2016-06-11.
  3. ^ Callaway, Ewen (2016). "UK scientists gain licence to edit genes in human embryos". Nature. 530 (7588): 18. Bibcode:2016Natur.530...18C. doi:10.1038/nature.2016.19270. PMID 26842037.
  4. ^ a b "Kathy Niakan". Crick. Retrieved 2019-02-15.
  5. ^ a b c "Kathy Niakan: Biography". Francis Crick Institute. Retrieved 15 February 2016.
  6. ^ "Our founders". Crick. Retrieved 2019-02-15.
  7. ^ "Kathy Niakan | Blavatnik Awards for Young Scientists". blavatnikawards.org. Retrieved 2019-01-10.
  8. ^ "Epigenetics programme welcomes Professor Kathy Niakan as honorary group leader | Babraham Institute". www.babraham.ac.uk. Retrieved 2021-10-03.
  9. ^ Gallagher, James (February 2016). "Scientists get 'gene editing' go-ahead". BBC News. Retrieved 15 February 2016.
  10. ^ Walsh, Fergus (2016-06-06). "Gene editing technique could transform future". BBC News. Retrieved 2016-06-11.
  11. ^ Fogarty, Norah M. E.; McCarthy, Afshan; Snijders, Kirsten E.; Powell, Benjamin E.; Kubikova, Nada; Blakeley, Paul; Lea, Rebecca; Elder, Kay; Wamaitha, Sissy E. (2017-09-20). "Genome editing reveals a role for OCT4 in human embryogenesis". Nature. 550 (7674): 67–73. Bibcode:2017Natur.550...67F. doi:10.1038/nature24033. ISSN 0028-0836. PMC 5815497. PMID 28953884.
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