KLRA1

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killer cell lectin-like receptor, subfamily A, member 2
Identifiers
OrganismMus musculus
SymbolKlra2
Alt. symbolsLy49b; Klra30
Entrez16633
RefSeq (mRNA)NM_008462.5
RefSeq (Prot)NP_032488.4
UniProtQ60660
Other data
Chromosome6: 131.22 - 131.25 Mb
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StructuresSwiss-model
DomainsInterPro
Killer cell lectin-like receptor subfamily A pseudogene 1
Identifiers
SymbolKLRAP1
Alt. symbolsKLRA1; Ly49; LY49L; Ly-49L
NCBI gene10748
HGNC6372
OMIM604274
RefSeqNM_006611
UniProtO75889
Other data
LocusChr. 12 p12-p13
Search for
StructuresSwiss-model
DomainsInterPro

Killer cell lectin-like receptor subfamily A (KLRA, alternative nomenclature Ly49) is a gene cluster coding proteins from family Ly49, which are membrane receptors expressed mainly on the surface of NK cells and other cells of immune system in some mammals including rodents and cattle but not humans.[1][2] Mouse Klra gene cluster is located on chromosome 6 and comprises 20-30 genes and pseudogenes, e.g. Klra1 (Ly49A).[2][3] Klra gene family is highly polymorphic and polygenic and various mouse strains encode different number of Klra genes.[2][4]

The homologous human KLRAP1 gene has been classified as a transcribed pseudogene because all associated transcripts are candidates for nonsense-mediated decay (NMD).[5][6]

References

  1. ^ Rahim MM, Tu MM, Mahmoud AB, Wight A, Abou-Samra E, Lima PD, Makrigiannis AP (2014-04-02). "Ly49 receptors: innate and adaptive immune paradigms". Frontiers in Immunology. 5: 145. doi:10.3389/fimmu.2014.00145. PMC 3980100. PMID 24765094.
  2. ^ a b c Schenkel AR, Kingry LC, Slayden RA (2013). "The ly49 gene family. A brief guide to the nomenclature, genetics, and role in intracellular infection". Frontiers in Immunology. 4: 90. doi:10.3389/fimmu.2013.00090. PMC 3627126. PMID 23596445.
  3. ^ "Klra MGI Mouse Complex/Cluster/Region Detail - MGI:96876 - killer cell lectin-like receptor, subfamily A". www.informatics.jax.org. Retrieved 2019-06-30.
  4. ^ Rahim MM, Makrigiannis AP (September 2015). "Ly49 receptors: evolution, genetic diversity, and impact on immunity". Immunological Reviews. 267 (1): 137–47. doi:10.1111/imr.12318. PMID 26284475. S2CID 13458485.
  5. ^ Barten R, Trowsdale J (July 1999). "The human Ly-49L gene". Immunogenetics. 49 (7–8): 731–4. doi:10.1007/s002510050675. PMID 10369937. S2CID 708709.
  6. ^ Hao L, Klein J, Nei M (February 2006). "Heterogeneous but conserved natural killer receptor gene complexes in four major orders of mammals". Proceedings of the National Academy of Sciences of the United States of America. 103 (9): 3192–7. Bibcode:2006PNAS..103.3192H. doi:10.1073/pnas.0511280103. PMC 1413923. PMID 16492762.

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