KIRREL2

KIRREL2
Identifiers
Aliases	KIRREL2, FILTRIN, NEPH3, NLG1, kin of IRRE like 2 (Drosophila), kirre like nephrin family adhesion molecule 2
External IDs	OMIM: 607762 MGI: 2442334 HomoloGene: 35249 GeneCards: KIRREL2
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.12 Start 35,855,861 bp End 35,867,136 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 B1 Start 30,146,959 bp End 30,157,115 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas islet of Langerhans ganglionic eminence retinal pigment epithelium prefrontal cortex external globus pallidus lymph node Brodmann area 9 cingulate gyrus putamen Top expressed in superior frontal gyrus respiratory epithelium islet of Langerhans spinal cord rhombic lip olfactory epithelium spinal ganglia medulla oblongata cerebellar cortex hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding identical protein binding Cellular component integral component of membrane slit diaphragm membrane plasma membrane cell-cell junction Biological process negative regulation of protein phosphorylation cell adhesion cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84063 243911 Ensembl ENSG00000126259 ENSMUSG00000036915 UniProt Q6UWL6 Q7TSU7 RefSeq (mRNA) NM_032123 NM_199179 NM_199180 NM_001329530 NM_001363667 NM_172898 RefSeq (protein) NP_001316459 NP_115499 NP_954648 NP_954649 NP_001350596 NP_766486 Location (UCSC) Chr 19: 35.86 – 35.87 Mb Chr 7: 30.15 – 30.16 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Kin of IRRE-like protein 2, also known as NEPH3, is a protein that in humans is encoded by the KIRREL2 gene. It is primarily expressed in β cells of the pancreatic islets.

KIRREL2 is a member of the NEPH protein family, which includes NEPH1 (KIRREL) and NEPH2 (KIRREL3).

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rinta-Valkama J, Aaltonen P, Lassila M, et al. (2007). "Densin and filtrin in the pancreas and in the kidney, targets for humoral autoimmunity in patients with type 1 diabetes". Diabetes Metab. Res. Rev. 23 (2): 119–26. doi:10.1002/dmrr.655. PMID 16741999. S2CID 30494486.