Jon A. Wolff

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Jon Asher Wolff (September 25, 1956 – April 17, 2020) was an American geneticist. He was the lead author on a 1990 study published in the journal Science that first suggested the possibility of synthesizing mRNA in a laboratory to trigger the production of a desired protein.[1][2] As of 2021, the article has been cited in the scholarly press more than 630 times and been described, by Nature, as "the first step toward making a vaccine from mRNA".[3][4]

Wolff was born in Bayside, Queens, New York, in 1956,[5][6] received his undergraduate education at Cornell University and earned an MD from Johns Hopkins University.[7] He was a professor of medicine at the University of Wisconsin and later founder of the biotechnology firm Mirus Bio.[3] He died in Denver, Colorado, from esophageal cancer at age 63.[5]

References

  1. ^ Jon A. Wolff; Robert Malone; Williams P; Chong W; Acsadi G; Jani A; Philip L. Felgner (1 March 1990). "Direct gene transfer into mouse muscle in vivo". Science. 247 (4949 Pt 1): 1465–1468. doi:10.1126/SCIENCE.1690918. ISSN 0036-8075. PMID 1690918. Wikidata Q44656494.
  2. ^ Hecking, Claus (June 23, 2021). "Hopes Are High for the Technology that Is Leading Us Out of the Pandemic". Der Spiegel. Retrieved July 31, 2021.
  3. ^ a b Jones, Trey (April 15, 2021). "The Lab Report: How former UW physician scientist changed gene therapy forever, inspiring COVID-19 vaccines". Badger Herald. Retrieved July 31, 2021.
  4. ^ May, Mike (May 31, 2021). "After COVID-19 successes, researchers push to develop mRNA vaccines for other diseases". Nature. 27 (6): 930–932. doi:10.1038/s41591-021-01393-8. PMID 34059823.
  5. ^ a b "Jon Wolff" (PDF). Crested Butte News. May 1, 2020. Retrieved August 4, 2021.
  6. ^ "Wolff, Jon A. (Jon Asher), 1956-". LC Linked Data Service. The Library of Congress. Retrieved 4 August 2021.
  7. ^ "Saying Goodbye to a Colleague and Friend". pediatrics.wisc.edu. University of Wisconsin. Retrieved July 31, 2021.


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