Jane Armitage

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Jane Armitage
OBE FRCP FFPH
Born
Jane Margaret Armitage
Scientific career
FieldsCardiovascular disease
Clinical trials
InstitutionsUniversity of Oxford
Clinical Trial Service Unit
Websitewww.ndph.ox.ac.uk/team/jane-armitage

Jane Margaret Armitage OBE FRCP FFPH is a professor of clinical trials and epidemiology in the Clinical Trial Service Unit at the University of Oxford. She works on the epidemiology of cardiovascular disease and has led large-scale randomized controlled trials.

Early life and education

Armitage qualified in medicine in 1979.[1] She worked in respiratory medicine, geriatrics and diabetes.[2]

Research and career

In 1990 Armitage joined the Clinical Trial Service Unit.[3] She has served as Director of Training & Career Development as well as leading the Medical Research Council Population Health Research Unit.[4] She is best known for her work on the safety of statins.[5]

Armitage led the 1999 Medical Research Council and British Heart Foundation Heart Protection Study, which included 20,000 participants.[6] The study is the largest that investigates the use of statins to prevent cardiovascular disease.[6] She was also the lead for the Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH) study and the Heart Protection Study 2 (HPS2) Treatment of HDL to Reduce the Incidence of Vascular Events (THRIVE) study.[6][7] She demonstrated that statins are also safe for patients with rheumatoid arthritis.[8]

Armitage was Chief Investigator for the ASCEND aspirin trial, which studied cardiovascular disease in 15,480 patients with diabetes.[9][10] ASCEND was the largest ever study that had every been performed to investigate whether aspirin should be used to prevent cardiovascular disease in diabetic patients.[10] The trial found that whilst aspirin reduces the risk of cardiovascular events by 12%, it increases the risk of major bleeding.[11] As an addition to the ASCEND study, Armitage was supported by Alzheimer's Research UK to study the impact of aspirin and fish oil on memory and cognition in patients with diabetes and Alzheimer's disease.[12] They also studied whether aspirin changes the risk of developing dementia and Alzheimer's disease. She also investigated whether fish oil and vitamin D supplements reduced cardiovascular disease in diabetic patients, but found they had no impact.[10][13]

She is an editor for the journal Atherosclerosis.[14]

Awards and honours

2019 Awarded an Officer of the Order of the British Empire for services to medical research[15]

References

  1. ^ Wren, Brenda (2014-12-16). The Medical Directory 2015. CRC Press. p. 196. ISBN 9781498728393.
  2. ^ "HPS Info : Biography : Jane Armitage". www.hpsinfo.org. Retrieved 2019-06-19.
  3. ^ "Jane Armitage—Nuffield Department of Population Health". www.ndph.ox.ac.uk. Retrieved 2019-06-19.
  4. ^ "Professor Jane Armitage recognised for services to medical research—Oxford Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU)". www.ctsu.ox.ac.uk. Retrieved 2019-06-19.
  5. ^ Armitage, Jane (2007-11-24). "The safety of statins in clinical practice". The Lancet. 370 (9601): 1781–1790. doi:10.1016/S0140-6736(07)60716-8. ISSN 0140-6736. PMID 17559928. S2CID 205948651.
  6. ^ a b c "Professor Jane Armitage | University of Oxford". www.ox.ac.uk. Retrieved 2019-06-19.
  7. ^ "THRIVE Home Page". www.thrivestudy.org. Retrieved 2019-06-19.
  8. ^ "Statins safe for preventing cardiovascular events in rheumatoid arthritis patients, study suggests". ScienceDaily. Retrieved 2019-06-20.
  9. ^ "ACCEL Lite: Featured ACCEL Interview With Erik Magnus Ohman and Jane Margaret Armitage". castbox.fm. Retrieved 2019-06-19.
  10. ^ a b c "Q&A: Jane Armitage, FRCP, FFPH, on the ASCEND Trial Results for Aspirin Benefits". MD Magazine. Retrieved 2019-06-19.
  11. ^ "ASCEND: Aspirin Not Needed for Primary Prevention in Diabetes". Medscape. Retrieved 2019-06-19.
  12. ^ "Oxford researchers to ask whether fish oils or aspirin could delay dementia". Alzheimer's Research UK. 2016-09-21. Archived from the original on 2019-06-20. Retrieved 2019-06-20.
  13. ^ "Heart meeting features fish oil, vitamin D, cholesterol news". Modern Healthcare. 2018-11-12. Retrieved 2019-06-20.
  14. ^ "Jane Armitage - European Atherosclerosis Society". www.eas-society.org. Retrieved 2019-06-19.
  15. ^ "New Year's Honours 2019 | University of Oxford". www.ox.ac.uk. 29 December 2018. Retrieved 2019-06-18.
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