Interferon-inducible GTPase
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| Interferon-inducible GTPase (IIGP) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 crystal structure of iigp1: a paradigm for interferon inducible p47 resistance gtpases | |||||||||
| Identifiers | |||||||||
| Symbol | IIGP | ||||||||
| Pfam | PF05049 | ||||||||
| Pfam clan | CL0023 | ||||||||
| InterPro | IPR007743 | ||||||||
| |||||||||
In molecular biology, the interferon-inducible GTPase (IIGP) family of proteins is thought to play a role in intracellular defence. IIGP is predominantly associated with the Golgi apparatus and also localises to the endoplasmic reticulum and exerts a distinct role in IFN-induced intracellular membrane trafficking or processing.[1]
Members of this family include interferon-inducible GTPase 5 and immunity-related GTPase family M protein.
References
- ^ Zerrahn J, Schaible UE, Brinkmann V, Guhlich U, Kaufmann SH (April 2002). "The IFN-inducible Golgi- and endoplasmic reticulum- associated 47-kDa GTPase IIGP is transiently expressed during listeriosis". J. Immunol. 168 (7): 3428–36. doi:10.4049/jimmunol.168.7.3428. PMID 11907101.