IPO8

IPO8
Identifiers
Aliases	IPO8, RANBP8, importin 8, VISS
External IDs	OMIM: 605600 MGI: 2444611 HomoloGene: 48430 GeneCards: IPO8
Gene location (Human) Chr. Chromosome 12 (human) Band 12p11.21 Start 30,628,988 bp End 30,695,869 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 G3 Start 148,770,683 bp End 148,831,467 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte internal globus pallidus Achilles tendon superficial temporal artery seminal vesicula jejunal mucosa rectum sural nerve endothelial cell renal medulla Top expressed in secondary oocyte cumulus cell medial vestibular nucleus pituitary gland superior cervical ganglion left lobe of liver dorsomedial hypothalamic nucleus parotid gland ureter primitive streak More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component cytoplasm nucleus nucleoplasm nuclear envelope cytosol Biological process protein transport intracellular protein transport signal transduction regulation of gene silencing by miRNA protein import into nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10526 320727 Ensembl ENSG00000133704 ENSMUSG00000040029 UniProt O15397 Q7TMY7 RefSeq (mRNA) NM_001190995 NM_006390 NM_001081113 RefSeq (protein) NP_001177924 NP_006381 NP_001074582 Location (UCSC) Chr 12: 30.63 – 30.7 Mb Chr 6: 148.77 – 148.83 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Importin 8 is a protein that in humans is encoded by the IPO8 gene.

Function

The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].

Further reading

• Görlich D, Dabrowski M, Bischoff FR, Kutay U, Bork P, Hartmann E, Prehn S, Izaurralde E (July 1997). "A novel class of RanGTP binding proteins". The Journal of Cell Biology. 138 (1): 65–80. doi:10.1083/jcb.138.1.65. PMC 2139951. PMID 9214382.
• Nozawa RS, Nagao K, Masuda HT, Iwasaki O, Hirota T, Nozaki N, Kimura H, Obuse C (July 2010). "Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation". Nature Cell Biology. 12 (7): 719–27. doi:10.1038/ncb2075. PMID 20562864. S2CID 7389788.
• Lunetta KL, D'Agostino RB, Karasik D, Benjamin EJ, Guo CY, Govindaraju R, Kiel DP, Kelly-Hayes M, Massaro JM, Pencina MJ, Seshadri S, Murabito JM (September 2007). "Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study". BMC Medical Genetics. 8 (Suppl 1): S13. doi:10.1186/1471-2350-8-S1-S13. PMC 1995604. PMID 17903295.
• Nguewa PA, Agorreta J, Blanco D, Lozano MD, Gomez-Roman J, Sanchez BA, Valles I, Pajares MJ, Pio R, Rodriguez MJ, Montuenga LM, Calvo A (November 2008). "Identification of importin 8 (IPO8) as the most accurate reference gene for the clinicopathological analysis of lung specimens". BMC Molecular Biology. 9: 103. doi:10.1186/1471-2199-9-103. PMC 2612021. PMID 19014639.
• Dean KA, von Ahsen O, Görlich D, Fried HM (October 2001). "Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin". Journal of Cell Science. 114 (Pt 19): 3479–85. doi:10.1242/jcs.114.19.3479. hdl:11858/00-001M-0000-0015-3D81-6. PMID 11682607.
• Weinmann L, Höck J, Ivacevic T, Ohrt T, Mütze J, Schwille P, Kremmer E, Benes V, Urlaub H, Meister G (February 2009). "Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs". Cell. 136 (3): 496–507. doi:10.1016/j.cell.2008.12.023. hdl:11858/00-001M-0000-0012-D8E1-E. PMID 19167051. S2CID 15876600.
• Yao X, Chen X, Cottonham C, Xu L (August 2008). "Preferential utilization of Imp7/8 in nuclear import of Smads". The Journal of Biological Chemistry. 283 (33): 22867–74. doi:10.1074/jbc.M801320200. PMC 2504884. PMID 18519565.
• Zuo S, Xue Y, Tang S, Yao J, Du R, Yang P, Chen X (July 2010). "14-3-3 epsilon dynamically interacts with key components of mitogen-activated protein kinase signal module for selective modulation of the TNF-alpha-induced time course-dependent NF-kappaB activity". Journal of Proteome Research. 9 (7): 3465–78. doi:10.1021/pr9011377. PMID 20462248.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.