IGHG1

IgG1 B12 heterotetramer, Human.

IGHG1
Identifiers
Aliases	IGHG1, immunoglobulin heavy constant gamma 1 (G1m marker)
External IDs	OMIM: 147100 GeneCards: IGHG1
Gene location (Human) Chr. Chromosome 14 (human) Band 14q32.33 Start 105,736,343 bp End 105,743,071 bp
Orthologs Species Human Mouse Entrez 3500 n/a Ensembl ENSG00000211896 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 14: 105.74 – 105.74 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Ig gamma-1 chain C region is a protein that in humans is encoded by the IGHG1 gene.

Further reading

• Ponstingl H, Hilschmann N (1977). "[The rule of antibody structure. The primary structure of a monoclonal IgG1 immunoglobulin (myeloma protein Nie). III. The chymotryptic peptides of the H-chain, alignment of the tryptic peptides and discussion of the complete structure]". Hoppe-Seyler's Z. Physiol. Chem. 357 (11): 1571–604. doi:10.1515/bchm2.1976.357.2.1571. PMID 826475.
• Dreker L, Schwarz J, Reichel W, Hilschmann N (1977). "[Rule of antibody structure. the primary structure of a monoclonal IgG1 immunoglobulin (myeloma protein Nie), I: Purification and characterization of the protein, the L- and H-chains, the cyanogenbromide cleavage products, and the disulfide bridges (author's transl)]". Hoppe-Seyler's Z. Physiol. Chem. 357 (11): 1515–40. doi:10.1515/bchm2.1976.357.2.1515. PMID 1002129.
• Brady RL, Edwards DJ, Hubbard RE, et al. (1992). "Crystal structure of a chimeric Fab' fragment of an antibody binding tumour cells". J. Mol. Biol. 227 (1): 253–64. doi:10.1016/0022-2836(92)90695-G. PMID 1522589.
• Gall WE, Edelman GM (1971). "The covalent structure of a human gamma G-immunoglobulin. X. Intrachain disulfide bonds". Biochemistry. 9 (16): 3188–96. doi:10.1021/bi00818a011. PMID 4923144.
• Cunningham BA, Rutishauser U, Gall WE, et al. (1971). "The covalent structure of a human gamma G-immunoglobulin. VII. Amino acid sequence of heavy-chain cyanogen bromide fragments H1-H4". Biochemistry. 9 (16): 3161–70. doi:10.1021/bi00818a008. PMID 5489771.
• Rutishauser U, Cunningham BA, Bennett C, et al. (1971). "The covalent structure of a human gamma G-immunoglobulin. 8. Amino acid sequence of heavy-chain cyanogen bromide fragments H5-H7". Biochemistry. 9 (16): 3171–81. doi:10.1021/bi00818a009. PMID 5530842.
• Ellison JW, Berson BJ, Hood LE (1982). "The nucleotide sequence of a human immunoglobulin C gamma1 gene". Nucleic Acids Res. 10 (13): 4071–9. doi:10.1093/nar/10.13.4071. PMC 320779. PMID 6287432.
• Takahashi N, Ueda S, Obata M, et al. (1982). "Structure of human immunoglobulin gamma genes: implications for evolution of a gene family". Cell. 29 (2): 671–9. doi:10.1016/0092-8674(82)90183-0. PMID 6811139. S2CID 31733882.
• Schmidt WE, Jung HD, Palm W, Hilschmann N (1983). "[Three-dimensional structure determination of antibodies. Primary structure of crystallized monoclonal immunoglobulin IgG1 KOL, I]". Hoppe-Seyler's Z. Physiol. Chem. 364 (6): 713–47. doi:10.1515/bchm2.1983.364.1.713. PMID 6884994.
• Deisenhofer J (1981). "Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution". Biochemistry. 20 (9): 2361–70. doi:10.1021/bi00512a001. PMID 7236608.
• Paterson T, Innes J, McMillan L, et al. (1998). "Variation in IgG1 heavy chain allotype does not contribute to differences in biological activity of two human anti-Rhesus (D) monoclonal antibodies". Immunotechnology. 4 (1): 37–47. doi:10.1016/S1380-2933(98)00005-0. PMID 9661813.
• Masat L, Caldwell J, Armstrong R, et al. (2000). "Association of SWAP-70 with the B cell antigen receptor complex". Proc. Natl. Acad. Sci. U.S.A. 97 (5): 2180–4. Bibcode:2000PNAS...97.2180M. doi:10.1073/pnas.040374497. PMC 15774. PMID 10681448.
• Sondermann P, Huber R, Oosthuizen V, Jacob U (2000). "The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex". Nature. 406 (6793): 267–73. doi:10.1038/35018508. PMID 10917521. S2CID 4306592.
• Hotta K, Lange H, Tantillo DJ, et al. (2000). "Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: crystal structures of abzyme 21D8". J. Mol. Biol. 302 (5): 1213–25. doi:10.1006/jmbi.2000.4503. PMID 11183784.
• McLean GR, Nakouzi A, Casadevall A, Green NS (2001). "Human and murine immunoglobulin expression vector cassettes". Mol. Immunol. 37 (14): 837–45. doi:10.1016/S0161-5890(00)00101-2. PMID 11257305.
• Karpusas M, Lucci J, Ferrant J, et al. (2001). "Structure of CD40 ligand in complex with the Fab fragment of a neutralizing humanized antibody". Structure. 9 (4): 321–9. doi:10.1016/S0969-2126(01)00590-1. PMID 11525169.
• Mimura Y, Sondermann P, Ghirlando R, et al. (2002). "Role of oligosaccharide residues of IgG1-Fc in Fc gamma RIIb binding". J. Biol. Chem. 276 (49): 45539–47. doi:10.1074/jbc.M107478200. PMID 11567028.
• Pandey JP, Frederick M (2002). "TNF-alpha, IL1-beta, and immunoglobulin (GM and KM) gene polymorphisms in sarcoidosis". Hum. Immunol. 63 (6): 485–91. doi:10.1016/S0198-8859(02)00399-3. PMID 12039524.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.