Protein-coding gene in the species Homo sapiens
Protein-S -isoprenylcysteine O -methyltransferase is an enzyme that in humans is encoded by the ICMT gene .[5] [6] [7]
This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane . This enzyme localizes to the endoplasmic reticulum . Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined.[7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000116237 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039662 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Dai Q, Choy E, Chiu V, Romano J, Slivka SR, Steitz SA, Michaelis S, Philips MR (Jul 1998). "Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum" . J Biol Chem . 273 (24): 15030–4. doi :10.1074/jbc.273.24.15030 PMID 9614111 . ^ Desrosiers RR, Nguyen QT, Beliveau R (Sep 1999). "The carboxyl methyltransferase modifying G proteins is a metalloenzyme". Biochem Biophys Res Commun . 261 (3): 790–7. doi :10.1006/bbrc.1999.0936 . PMID 10441503 . ^ a b "Entrez Gene: ICMT isoprenylcysteine carboxyl methyltransferase" .
Further reading
Choy E, Chiu VK, Silletti J, et al. (1999). "Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi" . Cell . 98 (1): 69–80. doi :10.1016/S0092-8674(00)80607-8 PMID 10412982 . S2CID 1018802 . Lin X, Antalffy B, Kang D, et al. (2000). "Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1". Nat. Neurosci . 3 (2): 157–63. doi :10.1038/72101 . PMID 10649571 . S2CID 2800058 . Van Dessel GA, De Busser HM, Lagrou AR (2002). "Prenylcysteine carboxymethyltransferase type III activity is decreased in retinoic acid-treated SH-SY5Y neuroblastoma cells". Int. J. Biochem. Cell Biol . 34 (5): 477–86. doi :10.1016/S1357-2725(01)00151-0 . PMID 11906819 . Ahmad M, Zhang Y, Zhang Y, et al. (2002). "Role of isoprenylcysteine carboxyl methyltransferase in tumor necrosis factor-alpha stimulation of expression of vascular cell adhesion molecule-1 in endothelial cells" . Arterioscler. Thromb. Vasc. Biol . 22 (5): 759–64. doi :10.1161/01.ATV.0000015884.61894.DC PMID 12006387 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Kramer K, Harrington EO, Lu Q, et al. (2004). "Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis" . Mol. Biol. Cell . 14 (3): 848–57. doi :10.1091/mbc.E02-07-0390 . PMC 151564 PMID 12631708 . Winter-Vann AM, Kamen BA, Bergo MO, et al. (2003). "Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate" . Proc. Natl. Acad. Sci. U.S.A . 100 (11): 6529–34. Bibcode :2003PNAS..100.6529W . doi :10.1073/pnas.1135239100 PMC 164480 PMID 12750467 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Bergo MO, Gavino BJ, Hong C, et al. (2004). "Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf" . J. Clin. Invest . 113 (4): 539–50. doi :10.1172/JCI18829 . PMC 338259 PMID 14966563 . Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol . 22 (6): 707–16. doi :10.1038/nbt971 . PMID 15146197 . S2CID 27764390 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Lu Q, Harrington EO, Newton J, et al. (2007). "Inhibition of ICMT induces endothelial cell apoptosis through GRP94" . Am. J. Respir. Cell Mol. Biol . 37 (1): 20–30. doi :10.1165/rcmb.2006-0301SM . PMC 1899353 PMID 17347446 .
