Heat shock protein family a (hsp70) member 12b

HSPA12B
Identifiers
Aliases	HSPA12B, C20orf60, dJ1009E24.2, heat shock protein family A (Hsp70) member 12B
External IDs	OMIM: 610702 MGI: 1919880 HomoloGene: 41749 GeneCards: HSPA12B
Gene location (Human) Chr. Chromosome 20 (human) Band 20p13 Start 3,732,685 bp End 3,753,111 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 F1 Start 130,969,200 bp End 130,988,241 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung subcutaneous adipose tissue spleen sperm upper lobe of left lung lactiferous duct lower lobe of lung endothelial cell canal of the cervix vena cava Top expressed in aortic valve ascending aorta external carotid artery internal carotid artery fossa right lung lobe yolk sac condyle smooth muscle tissue supraoptic nucleus More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 116835 72630 Ensembl ENSG00000132622 ENSMUSG00000074793 UniProt Q96MM6 Q9CZJ2 RefSeq (mRNA) NM_001197327 NM_052970 NM_001318322 NM_028306 RefSeq (protein) NP_001184256 NP_001305251 NP_443202 NP_001184256.1 NP_082582 Location (UCSC) Chr 20: 3.73 – 3.75 Mb Chr 2: 130.97 – 130.99 Mb PubMed search
Wikidata
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Heat shock protein family A (Hsp70) member 12B is a protein that in humans is encoded by the HSPA12B gene.

Function

The protein encoded by this gene contains an atypical heat shock protein 70 (Hsp70) ATPase domain and is therefore a distant member of the mammalian Hsp70 family. This gene may be involved in susceptibility to atherosclerosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].

Further reading

• Harris SE, Fox H, Wright AF, Hayward C, Starr JM, Whalley LJ, Deary IJ (July 2007). "A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition". BMC Genet. 8: 43. doi:10.1186/1471-2156-8-43. PMC 1933580. PMID 17601350.
• Starr JM, Shiels PG, Harris SE, Pattie A, Pearce MS, Relton CL, Deary IJ (December 2008). "Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey". Mech. Ageing Dev. 129 (12): 745–51. doi:10.1016/j.mad.2008.09.020. PMID 18977241. S2CID 35400326.
• Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (November 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
• Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (October 2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.
• Martins-de-Souza D, Guest PC, Mann DM, Roeber S, Rahmoune H, Bauder C, Kretzschmar H, Volk B, Baborie A, Bahn S (April 2012). "Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration". J. Proteome Res. 11 (4): 2533–43. doi:10.1021/pr2012279. PMID 22360420.
• Ma Y, Lu C, Li C, Li R, Zhang Y, Ma H, Zhang X, Ding Z, Liu L (January 2013). "Overexpression of HSPA12B protects against cerebral ischemia/reperfusion injury via a PI3K/Akt-dependent mechanism". Biochim. Biophys. Acta. 1832 (1): 57–66. doi:10.1016/j.bbadis.2012.10.003. PMID 23046810.
• Li J, Zhang Y, Li C, Xie J, Liu Y, Zhu W, Zhang X, Jiang S, Liu L, Ding Z (September 2013). "HSPA12B attenuates cardiac dysfunction and remodelling after myocardial infarction through an eNOS-dependent mechanism". Cardiovasc. Res. 99 (4): 674–84. doi:10.1093/cvr/cvt139. PMID 23729663.
• Zhang R, Wan XJ, Zhang X, Kang QX, Bian JJ, Yu GF, Wang JF, Zhu KM (2014). "Plasma HSPA12B is a potential predictor for poor outcome in severe sepsis". PLOS ONE. 9 (6): e101215. Bibcode:2014PLoSO...9j1215Z. doi:10.1371/journal.pone.0101215. PMC 4076283. PMID 24977412.
• Wu J, Li X, Huang L, Jiang S, Tu F, Zhang X, Ma H, Li R, Li C, Li Y, Ding Z, Liu L (March 2015). "HSPA12B inhibits lipopolysaccharide-induced inflammatory response in human umbilical vein endothelial cells". J. Cell. Mol. Med. 19 (3): 544–54. doi:10.1111/jcmm.12464. PMC 4369812. PMID 25545050.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.