HS6ST2
| HS6ST2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | HS6ST2, heparan sulfate 6-O-sulfotransferase 2, MRXSPM | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 300545 MGI: 1354959 HomoloGene: 9277 GeneCards: HS6ST2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Heparan sulfate 6-O-sulfotransferase 2 is a protein that in humans is encoded by the HS6ST2 gene. [5]
Function
Heparan sulfate proteoglycans are ubiquitous components of the cell surface, extracellular matrix, and basement membranes, and interact with various ligands to influence cell growth, differentiation, adhesion, and migration.
This gene encodes a member of the heparan sulfate (HS) sulfotransferase gene family, which catalyze the transfer of sulfate to HS. Different family members and isoforms are thought to synthesize heparan sulfates with tissue-specific structures and functions. Multiple transcript variants encoding different isoforms have been found for this gene.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000171004 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000062184 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Heparan sulfate 6-O-sulfotransferase 2". Retrieved 2016-07-11.
Further reading
- Habuchi H, Miyake G, Nogami K, Kuroiwa A, Matsuda Y, Kusche-Gullberg M, Habuchi O, Tanaka M, Kimata K (2003). "Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6-O-sulphotransferase-2 having different expression patterns and properties". Biochem. J. 371 (Pt 1): 131–42. doi:10.1042/BJ20021259. PMC 1223259. PMID 12492399.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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