HS3ST1

HS3ST1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZRH
Identifiers
Aliases	HS3ST1, 3OST, 3OST1, heparan sulfate-glucosamine 3-sulfotransferase 1
External IDs	OMIM: 603244 MGI: 1201606 HomoloGene: 3751 GeneCards: HS3ST1
Gene location (Human) Chr. Chromosome 4 (human) Band 4p15.33 Start 11,393,150 bp End 11,429,564 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 B3|5 21.14 cM Start 39,771,278 bp End 39,912,818 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell caput epididymis oral cavity palpebral conjunctiva mucosa of urinary bladder pancreatic epithelial cell gallbladder trachea cerebellar vermis pancreatic ductal cell Top expressed in cerebellar cortex cumulus cell olfactory bulb cerebellar vermis barrel cortex superior frontal gyrus medial geniculate nucleus iris respiratory epithelium olfactory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity sulfotransferase activity [heparan sulfate-glucosamine 3-sulfotransferase 1 activity] heparan sulfate sulfotransferase activity Cellular component Golgi lumen integral component of membrane Golgi apparatus Biological process glycosaminoglycan biosynthetic process heparan sulfate proteoglycan biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9957 15476 Ensembl ENSG00000002587 ENSMUSG00000051022 UniProt O14792 O35310 RefSeq (mRNA) NM_005114 NM_010474 RefSeq (protein) NP_005105 NP_034604 Location (UCSC) Chr 4: 11.39 – 11.43 Mb Chr 5: 39.77 – 39.91 Mb PubMed search
Wikidata
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Heparan sulfate glucosamine 3-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS3ST1 gene.

Function

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting enzyme for synthesis of anticoagulant heparan. This enzyme is an intraluminal Golgi resident protein.

Clinical significance

Polymorphisms in HS3ST1 appear to be a risk factor for developing Alzheimer's disease.

Further reading

• Razi N, Lindahl U (May 1995). "Biosynthesis of heparin/heparan sulfate. The D-glucosaminyl 3-O-sulfotransferase reaction: target and inhibitor saccharides". The Journal of Biological Chemistry. 270 (19): 11267–75. doi:10.1074/jbc.270.19.11267. PMID 7744762.
• Liu J, Shworak NW, Fritze LM, Edelberg JM, Rosenberg RD (October 1996). "Purification of heparan sulfate D-glucosaminyl 3-O-sulfotransferase". The Journal of Biological Chemistry. 271 (43): 27072–82. doi:10.1074/jbc.271.43.27072. PMID 8900198.
• Shworak NW, Liu J, Fritze LM, Schwartz JJ, Zhang L, Logeart D, Rosenberg RD (October 1997). "Molecular cloning and expression of mouse and human cDNAs encoding heparan sulfate D-glucosaminyl 3-O-sulfotransferase". The Journal of Biological Chemistry. 272 (44): 28008–19. doi:10.1074/jbc.272.44.28008. PMID 9346953.
• Liu J, Shworak NW, Sinaÿ P, Schwartz JJ, Zhang L, Fritze LM, Rosenberg RD (February 1999). "Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities". The Journal of Biological Chemistry. 274 (8): 5185–92. doi:10.1074/jbc.274.8.5185. PMID 9988768.
• Hernaiz M, Liu J, Rosenberg RD, Linhardt RJ (September 2000). "Enzymatic modification of heparan sulfate on a biochip promotes its interaction with antithrombin III". Biochemical and Biophysical Research Communications. 276 (1): 292–7. doi:10.1006/bbrc.2000.3453. PMID 11006120.
• Edavettal SC, Carrick K, Shah RR, Pedersen LC, Tropsha A, Pope RM, Liu J (April 2004). "A conformational change in heparan sulfate 3-O-sulfotransferase-1 is induced by binding to heparan sulfate". Biochemistry. 43 (16): 4680–8. doi:10.1021/bi0499112. PMID 15096036.

External links

• Overview of all the structural information available in the PDB for UniProt: O14792 (Human Heparan sulfate glucosamine 3-O-sulfotransferase 1) at the PDBe-KB.
• Overview of all the structural information available in the PDB for UniProt: O35310 (Mouse Heparan sulfate glucosamine 3-O-sulfotransferase 1) at the PDBe-KB.