HMGXB4

HMGXB4
Identifiers
Aliases	HMGXB4, Hmgxb4, 4733401K04Rik, AI316803, E430025G12, Hmgb2l1, HMG2L1, HMGBCG, THC211630, HMG-box containing 4, P53N
External IDs	OMIM: 604702 MGI: 1918073 HomoloGene: 4007 GeneCards: HMGXB4
Gene location (Human) Chr. Chromosome 22 (human) Band 22q12.3 Start 35,257,452 bp End 35,295,807 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 C1 Start 75,719,984 bp End 75,758,606 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte sperm sural nerve placenta tibia bone marrow urethra nipple embryo Top expressed in secondary oocyte primitive streak medullary collecting duct morula blastocyst ganglionic eminence maxillary prominence yolk sac vas deferens renal corpuscle More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding Cellular component NURF complex nucleus Biological process negative regulation of Wnt signaling pathway Wnt signaling pathway endosome to lysosome transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10042 70823 Ensembl ENSG00000100281 ENSMUSG00000034518 UniProt Q9UGU5 n/a RefSeq (mRNA) NM_001003681 NM_005487 NM_014250 NM_001362972 NM_178017 NM_001316753 NM_001316754 RefSeq (protein) NP_001003681 NP_001349901 n/a Location (UCSC) Chr 22: 35.26 – 35.3 Mb Chr 8: 75.72 – 75.76 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

HMG-box containing 4 is a protein that in humans is encoded by the HMGXB4 gene.

Function

High mobility group (HMG) proteins are nonhistone chromosomal proteins. See HMG2 (MIM 163906) for additional information on HMG proteins.[supplied by OMIM, Nov 2010].

Further reading

• Potash JB, Buervenich S, Cox NJ, Zandi PP, Akula N, Steele J, Rathe JA, Avramopoulos D, Detera-Wadleigh SD, Gershon ES, DePaulo JR, Feinberg AP, McMahon FJ (2008). "Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1". Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (1): 59–67. doi:10.1002/ajmg.b.30574. PMID 17671966.
• Potash JB, Buervenich S, Cox NJ, Zandi PP, Akula N, Steele J, Rathe JA, Avramopoulos D, Detera-Wadleigh SD, Gershon ES, DePaulo JR, Feinberg AP, McMahon FJ (2008). "Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1". Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (1): 59–67. doi:10.1002/ajmg.b.30574. PMID 17671966.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Zhou J, Hu G, Wang X (2010). "Repression of smooth muscle differentiation by a novel high mobility group box-containing protein, HMG2L1". J. Biol. Chem. 285 (30): 23177–85. doi:10.1074/jbc.M110.109868. PMC 2906311. PMID 20511232.
• Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A (2010). "Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study". Mutat. Res. 694 (1–2): 13–9. doi:10.1016/j.mrfmmm.2010.08.006. PMID 20800603.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.