HLA-A43

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HLA-A43
(MHC Class I, A cell surface antigen)
HLA-A43
About
Proteintransmembrane receptor/ligand
Structureαβ heterodimer
SubunitsHLA-A*4301, β2-microglobulin
Older namesA10
Subtypes
Subtype
allele
Available structures
A43 *4301
{{{cNick2}}} *43{{{cAllele2}}}
{{{cNick3}}} *43{{{cAllele3}}}
{{{cNick4}}} *43{{{cAllele4}}}
Alleles link-out to IMGT/HLA database at EBI

HLA-A43 (A43) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α43 subset of HLA-A α-chains. For A43, the alpha "A" chain are encoded by the HLA-A*43 allele group and the β-chain are encoded by B2M locus.[1] This group currently is dominated by A*4301. A43 and A*43 are almost synonymous in meaning. A43 is a split antigen of the broad antigen serotype A10. A43 is a sister serotype of A25, A26, A34, and A66.

Further information: History and naming of human leukocyte antigens

A43 is more common in Africa and SouthWest Asia. A43 is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele.[2].

Serotype

A43 recognition of some HLA A*43 gene products[3]
A*43 A43 A26 Sample
allele % % size (N)
*4301 0 35 9

A43 serotyping is poor.

Distribution

HLA A*4301 frequencies
freq
ref. Population (%)
[4] South Africa Tswana 4.9
[4] South African Natal Zulu 3.0
[4] China Yunnan Han 1.2
[4] Zambia Lusaka 1.2
[4] Pakistan Karachi Parsi 0.6
[4] India North Delhi 0.5
[4] Zimbabwe Harare Shona 0.4
[4] Italy 0.01
[4] China Shanghai 0.002

References

  1. ^ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
  2. ^ Madrigal JA, Hildebrand WH, Belich MP, et al. (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens. 41 (2): 72–80. doi:10.1111/j.1399-0039.1993.tb01982.x. PMID 8475492.
  3. ^ Allele Query Form IMGT/HLA - European Bioinformatics Institute
  4. ^ a b c d e f g h i Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.
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