Protein-coding gene in humans
Hepatocyte growth factor activator is a protein that in humans is encoded by the HGFAC gene .[5] [6] [7]
The protein encoded by this gene, belongs to peptidase family S1. It is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form.[7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000109758 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029102 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Miyazawa K, Shimomura T, Kitamura A, Kondo J, Morimoto Y, Kitamura N (Jun 1993). "Molecular Cloning and Sequence Analysis of the cDNA for a Human Serine Protease Responsible for Activation of Hepatocyte Growth Factor. Structural similarity of the protease precursor to blood coagulation factor XII" . J Biol Chem . 268 (14): 10024–8. doi :10.1016/S0021-9258(18)82167-6 PMID 7683665 . ^ Shimomura T, Kondo J, Ochiai M, Naka D, Miyazawa K, Morimoto Y, Kitamura N (Dec 1993). "Activation of the zymogen of hepatocyte growth factor activator by thrombin" . J Biol Chem . 268 (30): 22927–32. doi :10.1016/S0021-9258(18)41615-8 PMID 8226803 . ^ a b "Entrez Gene: HGFAC HGF activator" .
Further reading
Nakamura T (1992). "Structure and function of hepatocyte growth factor". Prog. Growth Factor Res . 3 (1): 67–85. doi :10.1016/0955-2235(91)90014-U . PMID 1838014 . Shimomura T, Ochiai M, Kondo J, Morimoto Y (1992). "A novel protease obtained from FBS-containing culture supernatant, that processes single chain form hepatocyte growth factor to two chain form in serum-free culture". Cytotechnology . 8 (3): 219–29. doi :10.1007/BF02522039 . PMID 1368819 . S2CID 24061579 . Miyazawa K, Shimomura T, Kitamura N (1996). "Activation of hepatocyte growth factor in the injured tissues is mediated by hepatocyte growth factor activator" . J. Biol. Chem . 271 (7): 3615–8. doi :10.1074/jbc.271.7.3615 PMID 8631970 . Shimomura T, Denda K, Kitamura A, et al. (1997). "Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor" . J. Biol. Chem . 272 (10): 6370–6. doi :10.1074/jbc.272.10.6370 PMID 9045658 . Kawaguchi T, Qin L, Shimomura T, et al. (1997). "Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor" . J. Biol. Chem . 272 (44): 27558–64. doi :10.1074/jbc.272.44.27558 PMID 9346890 . Miyazawa K, Wang Y, Minoshima S, et al. (1999). "Structural organization and chromosomal localization of the human hepatocyte growth factor activator gene--phylogenetic and functional relationship with blood coagulation factor XII, urokinase, and tissue-type plasminogen activator" . Eur. J. Biochem . 258 (2): 355–61. doi :10.1046/j.1432-1327.1998.2580355.x PMID 9874200 . Kataoka H, Shimomura T, Kawaguchi T, et al. (2001). "Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment" . J. Biol. Chem . 275 (51): 40453–62. doi :10.1074/jbc.M006412200 PMID 11013244 . Kataoka H, Meng JY, Itoh H, et al. (2001). "Localization of hepatocyte growth factor activator inhibitor type 1 in Langhans' cells of human placenta". Histochem. Cell Biol . 114 (6): 469–75. doi :10.1007/s004180000228 . PMID 11201608 . S2CID 25947109 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources" . Mol. Cell. Proteomics . 3 (4): 311–26. doi :10.1074/mcp.M300127-MCP200 PMID 14718574 . Tjin EP, Derksen PW, Kataoka H, et al. (2004). "Multiple myeloma cells catalyze hepatocyte growth factor (HGF) activation by secreting the serine protease HGF-activator" . Blood . 104 (7): 2172–5. doi :10.1182/blood-2003-12-4386 PMID 15172968 . Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites" . Protein Sci . 13 (10): 2819–24. doi :10.1110/ps.04682504 . PMC 2286551 PMID 15340161 . Shia S, Stamos J, Kirchhofer D, et al. (2005). "Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B". J. Mol. Biol . 346 (5): 1335–49. doi :10.1016/j.jmb.2004.12.048 . PMID 15713485 . Tjin EP, Groen RW, Vogelzang I, et al. (2006). "Functional analysis of HGF/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma" . Blood . 107 (2): 760–8. doi :10.1182/blood-2005-05-1929 PMID 16189274 . Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry" . J. Proteome Res . 4 (6): 2070–80. doi :10.1021/pr0502065 . PMC 1850943 PMID 16335952 .
