H60 family
Jump to navigation
Jump to search
The histocompatibility 60 (H60) was originally identified as a transplant rejection antigen[1] and it is a family of murine cell surface glycoproteins contains three members: H60a, H60b, H60c. The genes encoding these proteins are located on murine chromosome 10.[2] H60 family members are related to MHC class I.[2][3] H60a and H60b consist of external α1α2 domain, a transmembrane segment, and a cytoplasmic domain.[2][3] H60c is made up of α1α2 domain which is linked to the cell membrane by GPI anchor.[2] All these proteins function as stress-induced ligands for NKG2D receptor.[2][3]
References
- ^ Malarkannan, Subramaniam (1998). "The molecular and functional characterization of a dominant minor H antigen, H60". J. Immunol. 161 (7): 3501–9. doi:10.4049/jimmunol.161.7.3501. PMID 9759870. S2CID 2202196.
- ^ a b c d e Takada, Akio; Yoshida, Shigeru; Kajikawa, Mizuho; Miyatake, Yukiko; Tomaru, Utano; Sakai, Masaharu; Chiba, Hitoshi; Maenaka, Katsumi; Kohda, Daisuke (2008-02-01). "Two Novel NKG2D Ligands of the Mouse H60 Family with Differential Expression Patterns and Binding Affinities to NKG2D". The Journal of Immunology. 180 (3): 1678–1685. doi:10.4049/jimmunol.180.3.1678. ISSN 0022-1767. PMID 18209064.
- ^ a b c Cerwenka, Adelheid; Bakker, Alexander B. H.; McClanahan, Terri; Wagner, Janet; Wu, Jun; Phillips, Joseph H.; Lanier, Lewis L. (2000-01-06). "Retinoic Acid Early Inducible Genes Define a Ligand Family for the Activating NKG2D Receptor in Mice". Immunity. 12 (6): 721–727. doi:10.1016/S1074-7613(00)80222-8. ISSN 1074-7613. PMID 10894171.