Germacradienol synthase
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| Germacradienol synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.2.3.22 | ||||||||
| CAS no. | 211049-88-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Germacradienol synthase (EC 4.2.3.22, germacradienol/germacrene-D synthase, 2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol-forming]) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase ((1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol-forming).[1][2][3] This enzyme catalyses the following chemical reaction
- (2E,6E)-farnesyl diphosphate + H2O (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate
This enzyme requires Mg2+ for activity.
References
- ^ Cane DE, Watt RM (February 2003). "Expression and mechanistic analysis of a germacradienol synthase from Streptomyces coelicolor implicated in geosmin biosynthesis". Proceedings of the National Academy of Sciences of the United States of America. 100 (4): 1547–51. doi:10.1073/pnas.0337625100. PMC 149869. PMID 12556563.
- ^ He X, Cane DE (March 2004). "Mechanism and stereochemistry of the germacradienol/germacrene D synthase of Streptomyces coelicolor A3(2)". Journal of the American Chemical Society. 126 (9): 2678–9. doi:10.1021/ja039929k. PMID 14995166.
- ^ Gust B, Challis GL, Fowler K, Kieser T, Chater KF (February 2003). "PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin". Proceedings of the National Academy of Sciences of the United States of America. 100 (4): 1541–6. doi:10.1073/pnas.0337542100. PMC 149868. PMID 12563033.
External links
- Germacradienol+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
