Gaba type a receptor associated protein like 1

GABARAPL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L8J, 2R2Q
Identifiers
Aliases	GABARAPL1, APG8-LIKE, APG8L, ATG8, ATG8B, ATG8L, GEC1, GABA type A receptor associated protein like 1
External IDs	OMIM: 607420 MGI: 1914980 HomoloGene: 134420 GeneCards: GABARAPL1
Gene location (Human) Chr. Chromosome 12 (human) Band 12p13.2 Start 10,212,458 bp End 10,223,128 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 F3 Start 129,510,123 bp End 129,519,309 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 endothelial cell middle temporal gyrus pons parotid gland internal globus pallidus superior frontal gyrus kidney tubule orbitofrontal cortex superior vestibular nucleus Top expressed in hypothalamus hippocampus proper superior frontal gyrus kidney olfactory bulb cerebellar cortex renal cortex testicle lens proximal tubule More reference expression data BioGPS n/a
Gene ontology Molecular function GABA receptor binding Tat protein binding protein binding beta-tubulin binding ubiquitin protein ligase binding Cellular component cytoplasm cell body Golgi apparatus membrane intracellular anatomical structure dendrite membrane autophagosome endoplasmic reticulum mitochondrion dendrite cytoplasm microtubule cytoskeleton cytoplasmic vesicle membrane cytoplasmic vesicle autophagosome membrane cytosol Biological process autophagy macroautophagy autophagosome maturation autophagosome assembly autophagy of mitochondrion cellular response to nitrogen starvation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23710 57436 Ensembl ENSG00000139112 ENSMUSG00000030161 UniProt Q9H0R8 Q8R3R8 RefSeq (mRNA) NM_031412 NM_001363598 NM_020590 RefSeq (protein) NP_113600 NP_001350527 NP_065615 Location (UCSC) Chr 12: 10.21 – 10.22 Mb Chr 6: 129.51 – 129.52 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

GABA type A receptor associated protein like 1 is a protein that in humans is encoded by the GABARAPL1 gene.

Further reading

• Nemos C, Mansuy V, Vernier-Magnin S, Fraichard A, Jouvenot M, Delage-Mourroux R (2003). "Expression of gec1/GABARAPL1 versus GABARAP mRNAs in human: predominance of gec1/GABARAPL1 in the central nervous system". Brain Res. Mol. Brain Res. 119 (2): 216–9. doi:10.1016/j.molbrainres.2003.09.011. PMID 14625090.
• Chen C, Li JG, Chen Y, Huang P, Wang Y, Liu-Chen LY (2006). "GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor". J. Biol. Chem. 281 (12): 7983–93. doi:10.1074/jbc.M509805200. PMID 16431922.
• Chen Y, Chen C, Kotsikorou E, Lynch DL, Reggio PH, Liu-Chen LY (2009). "GEC1-kappa opioid receptor binding involves hydrophobic interactions: GEC1 has chaperone-like effect". J. Biol. Chem. 284 (3): 1673–85. doi:10.1074/jbc.M808303200. PMC 2615498. PMID 19001416.
• Betin VM, Lane JD (2009). "Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis". J. Cell Sci. 122 (Pt 14): 2554–66. doi:10.1242/jcs.046250. PMC 2704886. PMID 19549685.
• Berthier A, Seguin S, Sasco AJ, Bobin JY, De Laroche G, Datchary J, Saez S, Rodriguez-Lafrasse C, Tolle F, Fraichard A, Boyer-Guittaut M, Jouvenot M, Delage-Mourroux R, Descotes F (2010). "High expression of gabarapl1 is associated with a better outcome for patients with lymph node-positive breast cancer". Br. J. Cancer. 102 (6): 1024–31. doi:10.1038/sj.bjc.6605568. PMC 2844027. PMID 20197771.
• Johnatty SE, Beesley J, Chen X, Macgregor S, Duffy DL, Spurdle AB, deFazio A, Gava N, Webb PM, Rossing MA, Doherty JA, Goodman MT, Lurie G, Thompson PJ, Wilkens LR, Ness RB, Moysich KB, Chang-Claude J, Wang-Gohrke S, Cramer DW, Terry KL, Hankinson SE, Tworoger SS, Garcia-Closas M, Yang H, Lissowska J, Chanock SJ, Pharoah PD, Song H, Whitemore AS, Pearce CL, Stram DO, Wu AH, Pike MC, Gayther SA, Ramus SJ, Menon U, Gentry-Maharaj A, Anton-Culver H, Ziogas A, Hogdall E, Kjaer SK, Hogdall C, Berchuck A, Schildkraut JM, Iversen ES, Moorman PG, Phelan CM, Sellers TA, Cunningham JM, Vierkant RA, Rider DN, Goode EL, Haviv I, Chenevix-Trench G (2010). "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"". PLOS Genet. 6 (7): e1001016. doi:10.1371/journal.pgen.1001016. PMC 2900295. PMID 20628624.
• Le Grand JN, Chakrama FZ, Seguin-Py S, Fraichard A, Delage-Mourroux R, Jouvenot M, Boyer-Guittaut M (2011). "GABARAPL1 (GEC1): original or copycat?". Autophagy. 7 (10): 1098–107. doi:10.4161/auto.7.10.15904. PMID 21597319.
• Rozenknop A, Rogov VV, Rogova NY, Löhr F, Güntert P, Dikic I, Dötsch V (2011). "Characterization of the interaction of GABARAPL-1 with the LIR motif of NBR1". J. Mol. Biol. 410 (3): 477–87. doi:10.1016/j.jmb.2011.05.003. PMID 21620860.
• Jiang S, Wells CD, Roach PJ (2011). "Starch-binding domain-containing protein 1 (Stbd1) and glycogen metabolism: Identification of the Atg8 family interacting motif (AIM) in Stbd1 required for interaction with GABARAPL1". Biochem. Biophys. Res. Commun. 413 (3): 420–5. doi:10.1016/j.bbrc.2011.08.106. PMC 3411280. PMID 21893048.