Protein-coding gene in the species Homo sapiens
Granzyme H is a protein that in humans is encoded by the GZMH gene .[5] [6]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000100450 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015441 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Haddad P, Jenne D, Tschopp J, Clement MV, Mathieu-Mahul D, Sasportes M (Jul 1991). "Structure and evolutionary origin of the human granzyme H gene" (PDF) . Int Immunol . 3 (1): 57–66. doi :10.1093/intimm/3.1.57 . PMID 2049336 . ^ "Entrez Gene: GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)" .
Further reading
Waterhouse NJ, Trapani JA (2007). "H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells". Trends Immunol . 28 (9): 373–5. doi :10.1016/j.it.2007.08.001 . PMID 17766182 . Llorens C, Martres MP, Baudry M, Schwartz JC (1978). "Hypersensitivity to noradrenaline in cortex after chronic morphine: relevance to tolerance and dependence". Nature . 274 (5671): 603–5. Bibcode :1978Natur.274..603L . doi :10.1038/274603a0 . PMID 209336 . S2CID 4293645 . Heusel JW, Hanson RD, Silverman GA, Ley TJ (1991). "Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2" . J. Biol. Chem . 266 (10): 6152–8. doi :10.1016/S0021-9258(18)38097-9 PMID 2007574 . Meier M, Kwong PC, Frégeau CJ, et al. (1990). "Cloning of a gene that encodes a new member of the human cytotoxic cell protease family". Biochemistry . 29 (17): 4042–9. doi :10.1021/bi00469a003 . PMID 2193684 . Hanson RD, Hohn PA, Popescu NC, Ley TJ (1990). "A cluster of hematopoietic serine protease genes is found on the same chromosomal band as the human alpha/delta T-cell receptor locus" . Proc. Natl. Acad. Sci. U.S.A . 87 (3): 960–3. Bibcode :1990PNAS...87..960H . doi :10.1073/pnas.87.3.960 PMC 53389 PMID 2300587 . Klein JL, Selvakumar A, Trapani JA, Dupont B (1990). "Characterization of a novel, human cytotoxic lymphocyte-specific serine protease cDNA clone (CSP-C)". Tissue Antigens . 35 (5): 220–8. doi :10.1111/j.1399-0039.1990.tb01787.x . PMID 2402757 . MacIvor DM, Pham CT, Ley TJ (1999). "The 5' flanking region of the human granzyme H gene directs expression to T/natural killer cell progenitors and lymphokine-activated killer cells in transgenic mice". Blood . 93 (3): 963–73. doi :10.1182/blood.V93.3.963 . PMID 9920846 . Edwards KM, Kam CM, Powers JC, Trapani JA (1999). "The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes" . J. Biol. Chem . 274 (43): 30468–73. doi :10.1074/jbc.274.43.30468 PMID 10521426 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Johnson H, Scorrano L, Korsmeyer SJ, Ley TJ (2003). "Cell death induced by granzyme C" . Blood . 101 (8): 3093–101. doi :10.1182/blood-2002-08-2485 PMID 12515723 . Sedelies KA, Sayers TJ, Edwards KM, et al. (2004). "Discordant regulation of granzyme H and granzyme B expression in human lymphocytes" . J. Biol. Chem . 279 (25): 26581–7. doi :10.1074/jbc.M312481200 PMID 15069086 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Andrade F, Fellows E, Jenne DE, et al. (2007). "Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition" . EMBO J . 26 (8): 2148–57. doi :10.1038/sj.emboj.7601650 . PMC 1852776 PMID 17363894 . Fellows E, Gil-Parrado S, Jenne DE, Kurschus FC (2007). "Natural killer cell-derived human granzyme H induces an alternative, caspase-independent cell-death program" . Blood . 110 (2): 544–52. doi :10.1182/blood-2006-10-051649 PMID 17409270 .
