GLCE

GLCE
Identifiers
Aliases	GLCE, HSEPI, glucuronic acid epimerase
External IDs	OMIM: 612134 MGI: 2136405 HomoloGene: 14111 GeneCards: GLCE
Gene location (Human) Chr. Chromosome 15 (human) Band 15q23 Start 69,160,584 bp End 69,272,217 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 B Start 61,964,530 bp End 62,029,937 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere Achilles tendon ganglionic eminence rectum endothelial cell islet of Langerhans secondary oocyte monocyte minor salivary glands right lobe of liver Top expressed in saccule otic placode secondary oocyte cumulus cell medullary collecting duct nucleus accumbens habenula seminal vesicula olfactory tubercle stria vascularis More reference expression data BioGPS n/a
Gene ontology Molecular function racemase and epimerase activity, acting on carbohydrates and derivatives isomerase activity heparosan-N-sulfate-glucuronate 5-epimerase activity Cellular component integral component of membrane Golgi membrane Golgi apparatus membrane Biological process heparan sulfate proteoglycan biosynthetic process heparin biosynthetic process glycosaminoglycan biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26035 93683 Ensembl ENSG00000138604 ENSMUSG00000032252 UniProt O94923 Q9EPS3 RefSeq (mRNA) NM_015554 NM_001324091 NM_001324092 NM_001324093 NM_001324094 NM_033320 NM_001368304 RefSeq (protein) NP_001311020 NP_001311021 NP_001311022 NP_001311023 NP_056369 NP_201577 NP_001355233 Location (UCSC) Chr 15: 69.16 – 69.27 Mb Chr 9: 61.96 – 62.03 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

D-glucuronyl C5-epimerase is an enzyme that in humans is encoded by the GLCE gene.

Further reading

• Grigorieva E, Eshchenko T, Rykova VI, et al. (2008). "Decreased expression of human D-glucuronyl C5-epimerase in breast cancer". Int. J. Cancer. 122 (5): 1172–6. doi:10.1002/ijc.23203. PMID 17985344.
• Hagner-McWhirter A, Li JP, Oscarson S, Lindahl U (2004). "Irreversible glucuronyl C5-epimerization in the biosynthesis of heparan sulfate". J. Biol. Chem. 279 (15): 14631–8. doi:10.1074/jbc.M313760200. PMID 14718527.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Crawford BE, Olson SK, Esko JD, Pinhal MA (2001). "Cloning, Golgi localization, and enzyme activity of the full-length heparin/heparan sulfate-glucuronic acid C5-epimerase". J. Biol. Chem. 276 (24): 21538–43. doi:10.1074/jbc.M100880200. PMID 11279150.
• Li JP, Gong F, El Darwish K, et al. (2001). "Characterization of the D-glucuronyl C5-epimerase involved in the biosynthesis of heparin and heparan sulfate". J. Biol. Chem. 276 (23): 20069–77. doi:10.1074/jbc.M011783200. PMID 11274177.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.