Ftx (gene)

THCYTX
Identifiers
Aliases	FTXFtxThrombocytosisfamilial X-linked
External IDs	GeneCards: [1]
Orthologs
	84434
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	Wikidata
View/Edit Human

In molecular biology, FTX transcript, XIST regulator (non-protein coding), also known as FTX (Five prime to Xist), is a long non-coding RNA. In humans, it is located on the X chromosome. It was identified during sequence analysis of the X inactivation centre, surrounding the XIST gene.^[2] FTX contains several microRNAs within its introns.^[3] It upregulates expression of XIST, and inhibits DNA methylation of the XIST promoter.^[3]

References

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chureau C, Prissette M, Bourdet A, Barbe V, Cattolico L, Jones L, et al. (2002). "Comparative sequence analysis of the X-inactivation center region in mouse, human, and bovine". Genome Res. 12 (6): 894–908. doi:10.1101/gr.152902. PMC 1383731. PMID 12045143.
^ ^a ^b Chureau C, Chantalat S, Romito A, Galvani A, Duret L, Avner P, et al. (2011). "Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region". Hum Mol Genet. 20 (4): 705–718. doi:10.1093/hmg/ddq516. PMID 21118898.