Fructosamine-3-kinase

FN3K
Identifiers
Aliases	FN3K, fructosamine 3 kinase
External IDs	OMIM: 608425 MGI: 1926834 HomoloGene: 23336 GeneCards: FN3K
Gene location (Human) Chr. Chromosome 17 (human) Band 17q25.3 Start 82,735,615 bp End 82,751,196 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 E2 Start 121,325,739 bp End 121,341,317 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve prefrontal cortex right lobe of liver anterior pituitary Brodmann area 9 left ventricle body of stomach nucleus accumbens body of pancreas caudate nucleus Top expressed in interventricular septum facial motor nucleus anterior horn of spinal cord medial vestibular nucleus inferior colliculus medial dorsal nucleus superior frontal gyrus medial geniculate nucleus visual cortex motor neuron More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity kinase activity Cellular component cytosol cellular component Biological process post-translational protein modification epithelial cell differentiation fructoselysine metabolic process phosphorylation fructosamine metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64122 63828 Ensembl ENSG00000167363 ENSMUSG00000025175 UniProt Q9H479 Q9ER35 RefSeq (mRNA) NM_022158 NM_001038699 NM_022014 RefSeq (protein) NP_071441 NP_001033788 NP_071297 Location (UCSC) Chr 17: 82.74 – 82.75 Mb Chr 11: 121.33 – 121.34 Mb PubMed search
Wikidata
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Fructosamine-3-kinase is an enzyme that in humans is encoded by the FN3K gene.

Function

FN3K catalyzes phosphorylation of fructosamines formed by glycation, the nonenzymatic reaction of glucose with primary amines followed by Amadori rearrangement. Phosphorylation of fructosamines may initiate metabolism of the modified amine and result in deglycation of glycated proteins.

FN3K is responsible for the formation of fructose 3-phosphate (F3P), a compound identified in the lenses of diabetic rats. The spontaneous decomposition of F3P leads to the formation of 3-deoxyglucosone (3DG). 3DG contributes to diabetic complications. Treatment of normal and diabetic rats with an inhibitor of FN3K demonstrated a large reduction (~50%) in systemic 3DG in both groups. Removal of 3DG at its source by inhibition of FN3K is a viable option to treat diabetes related diseases since it would require a much smaller dose of drug.

Further reading

• Delpierre G, Rider MH, Collard F, et al. (2000). "Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase". Diabetes. 49 (10): 1627–34. doi:10.2337/diabetes.49.10.1627. PMID 11016445.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Delpierrre G, Vertommen D, Communi D, et al. (2004). "Identification of fructosamine residues deglycated by fructosamine-3-kinase in human hemoglobin". J. Biol. Chem. 279 (26): 27613–20. doi:10.1074/jbc.M402091200. PMID 15102834.
• Delplanque J, Delpierre G, Opperdoes FR, Van Schaftingen E (2004). "Tissue distribution and evolution of fructosamine 3-kinase and fructosamine 3-kinase-related protein". J. Biol. Chem. 279 (45): 46606–13. doi:10.1074/jbc.M407678200. PMID 15331600.
• Conner JR, Beisswenger PJ, Szwergold BS (2004). "The expression of the genes for fructosamine-3-kinase and fructosamine-3-kinase-related protein appears to be constitutive and unaffected by environmental signals". Biochem. Biophys. Res. Commun. 323 (3): 932–6. doi:10.1016/j.bbrc.2004.08.181. PMID 15381090.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Conner JR, Beisswenger PJ, Szwergold BS (2005). "Some clues as to the regulation, expression, function, and distribution of fructosamine-3-kinase and fructosamine-3-kinase-related protein". Ann. N. Y. Acad. Sci. 1043 (1): 824–36. Bibcode:2005NYASA1043..824C. doi:10.1196/annals.1333.095. PMID 16037310. S2CID 19916880.
• Delpierre G, Veiga-da-Cunha M, Vertommen D, et al. (2006). "Variability in erythrocyte fructosamine 3-kinase activity in humans correlates with polymorphisms in the FN3K gene and impacts on haemoglobin glycation at specific sites". Diabetes Metab. 32 (1): 31–9. doi:10.1016/S1262-3636(07)70244-6. PMID 16523184.

See also

• Protein-fructosamine 3-kinase