File:Nicotine Exposure of Female Mice Alters Epigenetic Factors in First-Generation (F1) and Second-Generation (F2) Offspring.jpg
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_and_Second-Generation_(F2)_Offspring.jpg){kind=link}
Summary
| Description |
The figure indicates the effect of nicotine exposure of female mice on epigenetic factors in F1 offspring (left panel) and F2 offspring (right panel). In each panel, the left column represents samples from the frontal cortex, the middle column represents samples from the striatum, and the right column represents samples from the hippocampus. The six rows in each panel represent the different epigenetic factors analyzed. A color bar at the bottom represents the levels of the epigenetic factors compared with those in F1 offspring of control animals on a scale from -60% to +160%. Reduced levels compared with control animals are indicted by red shading, similar levels to control animals are indicated by gray shading, and increased levels compared with control animals are indicated by green shading. One, two, or three asterisks within a field indicate differences at varying levels of statistical significance. Expression of DNMT3A (row 1) was significantly reduced in the frontal cortex and striatum of both F1 and F2 offspring nicotine-exposed mice. Expression of MeCP2 (row 3) and HDAC2 (row 5) was significantly reduced in the frontal cortex and hippocampus of both F1 and F2 offspring of nicotine-exposed mice. Expression of pHDAC2 was significantly increased in the frontal cortex and hippocampus, and significantly decreased in the striatum, of both F1 and F2 offspring of nicotine-exposed mice. Expression of TET2 (row 2) and pMECP2 (row 4) did not differ significantly between F1 or F2 offspring of nicotine-exposed mice and F1 offspring of control mice in any of the brain regions analyzed. |
| Date | |
| Source | https://archives.nida.nih.gov/news-events/nida-notes/2021/09/developmental-nicotine-exposure-in-mice-affects-epigenetic-factors-in-the-brain-across-multiple-generations |
| Author | Stacey C. Tobin |
Licensing
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This image is a work of the National Institutes of Health, part of the United States Department of Health and Human Services, taken or made as part of an employee's official duties. As a work of the U.S. federal government, the image is in the public domain.
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| This file has been identified as being free of known restrictions under copyright law, including all related and neighboring rights. | ||
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 16:41, 5 March 2024 | | 920 × 750 (115 KB) | commons>Ameisenigel | {{Information |Description=The figure indicates the effect of nicotine exposure of female mice on epigenetic factors in F1 offspring (left panel) and F2 offspring (right panel). In each panel, the left column represents samples from the frontal cortex, the middle column represents samples from the striatum, and the right column represents samples from the hippocampus. The six rows in each panel represent the different epigenetic factors analyzed. A color bar at the bottom represents the level... |
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_and_Second-Generation_(F2)_Offspring.jpg){kind=link}