File:Jbm-9-067Fig1.jpg

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Jbm-9-067Fig1.jpg ‎(758 × 566 pixels, file size: 99 KB, MIME type: image/jpeg)

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Summary

Description
English: Figure 1 Mechanism of inotuzumab ozogamicin.

Notes: Inotuzumab ozogamicin binds to the CD22 receptor of B cells and is internalized as a CD22–ADC complex. It is trafficked from endosome to lysosome with decreasing pH from 6 to 4, leading to degradation of an acid labile linker. This leads to the release and activation of the toxin calicheamicin as the antibody degrades. In the nucleus, calicheamicin intercalates in DNA, leading to apoptosis in targeted cells.

Abbreviation: ADC, antibody-drug conjugate.
Date
Source https://www.dovepress.com/inotuzumab-ozogamicin-in-the-treatment-of-relapsedrefractory-acute-b-c-peer-reviewed-fulltext-article-JBM
Author Uy N, Nadeau M , Stahl M, Zeidan AM

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