File:Gr1Plerixafor.jpg

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Gr1Plerixafor.jpg ‎(533 × 398 pixels, file size: 55 KB, MIME type: image/jpeg)

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Summary

Description
English: Figure 1Mechanisms of stem cell mobilization. G-CSF mobilizes CD34+ cells via down-regulation of SDF-1 expression and induction of CD26/dipeptidyl peptidase IV (DPPIV) cleavage of cell surface SDF-1. In addition, G-CSF stimulates polymorphonuclear leukocyte cell release of the proteases NE, CG, and MMP-9, which cleave VCAM-1, c-kit, and SDF-1, releasing stem cells from the bone marrow into the peripheral blood. Plerixafor mobilizes stem cells through direct antagonism of CXCR4, which inhibits the interaction of SDF-1 with CXCR4
Date
Source https://www.astctjournal.org/article/S1083-8791(10)00057-1/fulltext
Author

Stefan Fruehauf

Guido Tricot

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English: This file is licensed CC BY-NC-ND 4.0

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current20:14, 27 May 2024Thumbnail for version as of 20:14, 27 May 2024533 × 398 (55 KB)Ozzie10aaaaUploaded a work by Stefan Fruehauf Guido Tricot from https://www.astctjournal.org/article/S1083-8791(10)00057-1/fulltext with UploadWizard

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