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DescriptionDDDT-127568-F02 (cropped).jpg	English: Figure 2 Mechanism of action of romosozumab. Notes: Romosozumab is a human monoclonal antibody that binds sclerostin (an inhibitor of Wnt pathway signaling). When this monoclonal antibody binds to sclerostin, sclerostin cannot bind to the LRP-5 and LRP-6 receptors and is unable to exert its inhibitory effect. Wnt binds to LRP-5 or LRP-6 coreceptors and specific Frizzled family receptor, leading to activation of the Wnt signaling pathway and bone formation. Copyright ©2015. Dove Medical Press. Shah AD, Shoback D, Lewiecki EM. Sclerostin inhibition: a novel therapeutic approach in the treatment of osteoporosis. Int J Womens Health. 2015;7:565–580.7 Abbreviation: LRP, LDL-receptor-related protein.
Date	2016
Source	https://www.dovepress.com/profile-of-romosozumab-and-its-potential-in-the-management-of-osteopor-peer-reviewed-fulltext-article-DDDT
Author	Lim SY , Bolster MB
Other-versions	Lua error in Module:Autotranslate at line 77: No fallback page found for autotranslate (base=Extracted from, lang=⧼lang⧽).

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